1234923-61-5Relevant academic research and scientific papers
Activity of siRNAs with 2-thio-2'-O-methyluridine modification in mammalian cells
Prakash, Thazha P.,Naik, Nishant,Sioufi, Namir,Bhat, Balkrishen,Swayze, Eric E.
, p. 902 - 910 (2009)
In a search to identify chemical modifications to improve the properties of siRNA, we have investigated the effect of the 2'-O-methyl-2-thiouridine modification on the biological activity of siRNA. Our results indicate that judicious placement of 2'-O-met
