1235102-80-3Relevant academic research and scientific papers
Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
Venugopala, Katharigatta N.,Chandrashekharappa, Sandeep,Deb, Pran Kishore,Tratrat, Christophe,Pillay, Melendhran,Chopra, Deepak,Al-Shar’i, Nizar A.,Hourani, Wafa,Dahabiyeh, Lina A.,Borah, Pobitra,Nagdeve, Rahul D.,Nayak, Susanta K.,Padmashali, Basavaraj,Morsy, Mohamed A.,Aldhubiab, Bandar E.,Attimarad, Mahesh,Nair, Anroop B.,Sreeharsha, Nagaraja,Haroun, Michelyne,Shashikanth, Sheena,Mohanlall, Viresh,Mailavaram, Raghuprasad
, p. 1472 - 1487 (2021)
A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in?vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a
Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis
Sandeep, Chandrashekharappa,Venugopala, Katharigatta N.,Gleiser, Raquel M.,Chetram, Abeen,Padmashali, Basavaraj,Kulkarni, Rashmi S.,Venugopala, Rashmi,Odhav, Bharti
, p. 899 - 904 (2016)
Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron-deficient alkynes in the presence of water as the base and solvent at 80?°C. Yield of the title compounds was
Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines
Chen, Zhengwang,Liang, Pei,Ma, Xiaoyue,Luo, Haiqing,Xu, Guohai,Liu, Tanggao,Wen, Xiaowei,Zheng, Jing,Ye, Hui
, p. 1630 - 1639 (2019/01/26)
A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.
Copper acetate monohydrate: A cheap but efficient oxidant for synthesizing multi-substituted indolizines from pyridinium ylides and electron deficient alkenes
Hu, Huayou,Feng, Junjun,Zhu, Yulan,Gu, Ning,Kan, Yuhe
, p. 8637 - 8644 (2015/02/19)
We report a highly practical one-pot method for synthesizing multi-substituted indolizines from ?±-halide carbonyl compounds, pyridines and electron deficient alkenes in the presence of copper acetate monohydrate and sodium acetate in DMF. A variety of function groups are tolerable in standard reaction conditions, including aldehyde. 36 examples were presented. The yield of indolizine was from moderate to high. Furthermore, multi-substituted indolizines can be prepared at gram scale by this method.
Facile approach to diverse 3-acylated indolizines via a sequential Sonogashira coupling/iodocyclization process
Jung, Youngeun,Kim, Ikyon
experimental part, p. 8198 - 8206 (2012/09/22)
Successful implementation of a sequential Pd-catalyzed Sonogashira cross-coupling/iodine-promoted 5-exo-dig cyclization procedure with pyridines bearing a terminal alkyne moiety provided direct and straightforward access to a diverse array of 3-acylated i
