1235126-46-1Relevant articles and documents
A pair of windmill-shaped enantiomers from lindera aggregata with activity toward improvement of insulin sensitivity
Wang, Fei,Gao, Yuan,Zhang, Ling,Bai, Bing,Hu, Ya Nan,Dong, Ze Jun,Zhai, Qi Wei,Zhu, Hua Jie,Liu, Ji Kai
, p. 3196 - 3199 (2010)
(Figure Presented) (+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance.
Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways
Tan, Haibo,Zheng, Chao,Liu, Zheng,Wang, David Zhigang
, p. 2192 - 2195 (2011/06/25)
Chemical equations presented. Simple exposure to sunlight is sufficient for triggering photochemical [2 + 2] cycloaddition-Cope or radical rearrangement cascades in the naturally occurring methyl linderone, leading to efficient biomimetic total syntheses of linderaspirone A and bi-linderone, two recently discovered bioactive spirocyclopentenedione natural products.