3984-73-4

Usage

Uses

Used in Electrochemical Applications:
Methyllinderone is used as a redox mediator for its ability to facilitate electron transfer in electrochemical reactions, enhancing the efficiency and performance of electrochemical systems.
Used in Energy Storage Devices:
In the Energy Storage Industry, Methyllinderone is used as a component in batteries and supercapacitors due to its high conductivity and redox potential, which contribute to improved energy storage capacity and power delivery.
Used in Antioxidant Formulations:
Methyllinderone is utilized as an antioxidant for its potential to neutralize harmful free radicals, thereby protecting cells and tissues from oxidative damage and contributing to health and longevity.
Used in Oncology Research:
In the field of Oncology, Methyllinderone is studied for its ability to inhibit the growth of certain types of cancer cells, making it a candidate for further research into cancer treatment and therapy development.

Upstream product

• 124-41-4 sodium methylate 
• 361147-57-1 2-((E)-1-Bromo-3-phenyl-allylidene)-4,5-dimethoxy-cyclopent-4-ene-1,3-dione 
• 361147-55-9 4-hydroxy-2,3-dimethoxy-4-(4-phenyl-but-1-ynyl)-cyclobut-2-enone 
• 361147-56-0 2-(1-bromo-3-phenyl-propylidene)-4,5-dimethoxy-cyclopent-4-ene-1,3-dione 
• 186581-53-3 diazomethane 
• 93012-70-5 Linderone 
• 1283099-20-6 (E)-3,4-dimethoxy-5-((E)-2-oxo-4-phenylbut-3-en-1-ylidene)furan-2(5H)-one 
• 1283099-18-2 (E)-4-hydroxy-2,3-dimethoxy-4-(2-oxo-4-phenylbut-3-en-1-yl)cyclobut-2-enone 
• 102-92-1 cinnamoyl chloride 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 
• 161033-73-4 4-(1,3-dithian-2-yl)-4-hydroxy-2,3-dimethoxycyclobut-2-enone 
• 1283099-19-3 (E)-3,4-dimethoxy-5-oxo-2-(2-oxo-4-phenylbut-3-en-1-yl)-2,5-dihydrofuran-2-yl acetate 

Downstream Products

• 1227375-09-8 (+/-)-bi-linderone 
• 1235126-46-1 (+/-)-linderaspirone A 
• 1235126-53-0 linderaspirone A 
• 1227375-09-8 bilinderone 
• 1227375-09-8 epi-bi-linderone 

Relevant academic research and scientific papers

Natural product-based pesticide discovery: Design, synthesis and bioactivity studies of N-amino-maleimide derivatives

Natural products are an important source of pesticide discovery. A series of N-amino-maleimide derivatives containing hydrazone group were designed and synthesized based on the structure of linderone and methyllinderone which were isolated from Lindera erythrocarpa Makino. According to the bioassay results, compounds 2 and 3 showed 60% inhibition against mosquito (Culex pipiens pallens) at 0.25 μg·mL?1. Furthermore, the results of antifungal tests indicated that most compounds exhibited much better antifungal activities against fourteen phytopathogenic fungi than linderone and methyllinderone and some compounds exhibited better antifungal activities than commercial fungicides (carbendazim and chlorothalonil) at 50 μg·mL?1. In particular, compound 12 exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 11 phytopathogenic fungi) and compounds 12 and 14 displayed 60.6% and 47.9% inhibitory activity against Rhizoctonia cerealis at 12.5 μg·mL?1 respectively. Furthermore, compound 17 was synthesized, which lacks N-substituent at maleimide and its poor antifungal activity against Sclerotinia sclerotiorum and Rhizoctonia cerealis at 50 μg·mL?1 showed that the backbone structure of N-amino-maleimide derivatives containing hydrazone group was important to the antifungal activity.

Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways

Chemical equations presented. Simple exposure to sunlight is sufficient for triggering photochemical [2 + 2] cycloaddition-Cope or radical rearrangement cascades in the naturally occurring methyl linderone, leading to efficient biomimetic total syntheses of linderaspirone A and bi-linderone, two recently discovered bioactive spirocyclopentenedione natural products.

Total synthesis of human chymase inhibitor methyllinderone and structure - Activity relationships of its derivatives

Total synthesis of human chymase inhibitor methyllinderone has been achieved in only four steps with an overall yield of 21% from dimethyl squarate. We developed an efficient synthetic method for obtaining methyllinderone derivatives and found the active compound. In addition, we propose the inhibition mechanism of the active compound against human chymase using calculations.