161689-53-8Relevant academic research and scientific papers
Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity
Betti, Marco,Catarzi, Daniela,Varano, Flavia,Falsini, Matteo,Varani, Katia,Vincenzi, Fabrizio,Pasquini, Silvia,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Lucarini, Elena,Dal Ben, Diego,Spinaci, Andrea,Bartolucci, Gianluca,Menicatti, Marta,Colotta, Vittoria
, p. 6894 - 6912 (2019)
A new series of amino-3,5-dicyanopyridines (1-31) was synthesized and biologically evaluated in order to further investigate the potential of this scaffold to obtain adenosine receptor (AR) ligands. In general, the modifications performed have led to comp
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics
May, Barnaby C. H.,Zorn, Julie A.,Witkop, Juanita,Sherrill, John,Wallace, Andrew C.,Legname, Giuseppe,Prusiner, Stanley B.,Cohen, Fred E.
, p. 65 - 73 (2007/10/03)
2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.
CYCLIZATION REACTIONS OF NITRILES. LIV. SYNTHESIS AND PROPERTIES OF 6-AMINO-4-ARYL-3,5-DICYANOPYRIDIN-2(1H)-ONES, THE CORRESPONDING THIONES, THE PYRIDYLIDENEMALONONITRILES, AND THEIR HYDROGENATED ANALOGS
Sharanin, Yu. A.,Krivokolysko, S. G.,Dyachenko, V. D.
, p. 620 - 626 (2007/10/02)
The reactions of arylmethylenecyanothioacetamides with cyanoacetamide, cyanothioacetamide, and the malononitrile dimer in the presence of N-methylmorpholine lead to the formation of substituted 1,4-dihydropyridyn-2-olates, 1,4-dihydropyridine-2-thiolates, and N-methylmorpholinium dicyanomethanides.During acidification 1,4-dihydropyridine-2-thiolates give 3,4-dihydropyridine- and pyridine-2(1H)-thiones.The latter were used in the synthesis of alkylthiopyridines and 1,4-dihydropyridines and also the corresponding thienopyridines and thiazolopyridinium triiodide.
