123530-18-7

Upstream product

• 184241-00-7 1,4,8-tris(carboethoxymethyl)-1,4,8,11-tetraazacyclotetradecane 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 123530-13-2 11-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane 
• 295-37-4 1,4,8,11-Tetraazacyclotetradecane 
• 207393-00-8 [8,11-Bis-benzyloxycarbonylmethyl-4-(4-nitro-benzyl)-1,4,8,11-tetraaza-cyclotetradec-1-yl]-acetic acid benzyl ester 
• 121433-28-1 1,4,11-tris(carboxymethyl)-8-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane 

Relevant academic research and scientific papers

A convenient, novel approach for the synthesis of polyaza macrocyclic bifunctional chelating agents

The convenient synthetically useful bifunctional chelating agents, (10-p-aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (p-ABz-DO3A) 3 and (11-p-aminobenzyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-triacetate (p-ABz-TE3A) 6, were obtained by reaction of an ethyl bromoacetate with 1,4,7,10-tetraazacyclododecane and 1,4,8,11-tetraazacyclotetradecane followed by reaction with nitrobenzyl bromide. This method proved more efficient than any described in the literature since the overall yield in a two-step synthesis sequence starting from tetraazamacrocycles was 68%.

A new convenient synthesis of bifunctional chelating agent 1-(4- aminobenzyl)-1,4,8,11-tetraazacyclotetradecane-N',N'',N'''-triacetic acid [1- (H2NBn-TETA)]

A convenient and short synthesis (3 steps, 50% overall yield) of the bifunctional chelating agent 1-(4-aminobenzyl)-1,4,8,11 - tetraazacyclotetradecane - N'-, N''-, N'''- triacetic acid (4) via a boron- protection strategy is reported.