123530-61-0Relevant academic research and scientific papers
HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
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Page/Page column 71; 72, (2012/08/08)
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
Pyrimidinone compounds
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Page/Page column 24, (2008/06/13)
Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
Boyd, Helen F.,Hammond, Beverley,Hickey, Deirdre M.B.,Ife, Robert J.,Leach, Colin A.,Lewis,Macphee, Colin H.,Milliner, Kevin J.,Pinto, Ivan L.,Smith, Stephen A.,Stansfield, Ian G.,Theobald, Colin J.,Whittaker, Caroline M.
, p. 701 - 704 (2007/10/03)
Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties
N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2
Boyd, Helen F.,Fell, Stephen C. M.,Flynn, Sean T.,Hickey, Deirdre M. B.,Ife, Robert J.,Leach, Colin A.,Macphee, Colin H.,Milliner, Kevin J.,Moores, Kitty E.,Pinto, Ivan L.,Porter, Rod A.,Rawlings,Smith, Stephen A.,Stansfield, Ian G.,Tew, David G.,Theobald, Colin J.,Whittaker, Caroline M.
, p. 2557 - 2561 (2007/10/03)
From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human lipoprotein-associated phopholipase A2. These compounds show greatly enhanced activity in isolated plasma. Selected derivatives such as compounds 51 and 52 are orally active with a good duration of action. (C) 2000 Elsevier Science Ltd.
