123530-66-5 Usage
Uses
Used in Pharmaceutical and Agrochemical Industries:
(E)-3-(pyrazin-2-yl)acrylic acid is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products.
Used in Dye and Pigment Production:
(E)-3-(pyrazin-2-yl)acrylic acid is also utilized in the production of dyes, pigments, and other fine chemicals, highlighting its versatility in different industrial applications.
Used in Drug Discovery and Medicinal Chemistry Research:
Due to its potential biological activities and interactions with various biological targets, (E)-3-(pyrazin-2-yl)acrylic acid plays a significant role in drug discovery and medicinal chemistry research, aiding in the advancement of novel therapeutic agents.
It is crucial to handle (E)-3-(pyrazin-2-yl)acrylic acid with care, as it may pose health and environmental hazards if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 123530-66-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,5,3 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 123530-66:
(8*1)+(7*2)+(6*3)+(5*5)+(4*3)+(3*0)+(2*6)+(1*6)=95
95 % 10 = 5
So 123530-66-5 is a valid CAS Registry Number.
123530-66-5Relevant academic research and scientific papers
Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents
Zou, Yu,Yan, Chang,Zhang, Huibin,Xu, Jinyi,Zhang, Dayong,Huang, Zhangjian,Zhang, Yihua
, p. 313 - 319 (2017/07/07)
Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their death by triggering various pathways, including apoptosis, necrosis and autophagy. However, the poor solubility is a serious concern for intensive study and clinical application. We synthesized its analogs 1–9 by replacement of the trimethoxyphenyl of PL with an N-heteroaromatic ring and/or not introduction of 2-Cl. These compounds improved aqueous solubility and displayed potent anticancer activity. The most active compound 9 selectively enhanced ROS levels in colon cancer cells and inhibited the cell proliferation but sparing non-tumor colon cells. Importantly, 9 significantly repressed tumor growth in an HCT-116 xenograft mouse model, suggesting that these N-heteroaromatic ring-based analogs of PL warrant further investigation.
