5521-60-8 Usage
Uses
Used in Organic Synthesis:
5-Methyl-2,3-pyrazinedicarboxylic acid is used as a key intermediate in organic synthesis for the preparation of a variety of organic compounds. Its unique structure, including the 5-methyl group and carboxylic acid functionalities, allows for the creation of diverse chemical entities with potential applications in various fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Methyl-2,3-pyrazinedicarboxylic acid is utilized as a starting material for the development of new drugs and medications. Its potential biological activities make it a valuable candidate for the exploration of novel treatments for various diseases and conditions.
Used in Medicinal Chemistry:
5-Methyl-2,3-pyrazinedicarboxylic acid is employed in medicinal chemistry as a structural component in the design and synthesis of bioactive molecules. Its presence in a molecule can influence pharmacokinetic and pharmacodynamic properties, contributing to the optimization of drug candidates for improved efficacy and safety.
Used in Drug Discovery:
As part of drug discovery efforts, 5-Methyl-2,3-pyrazinedicarboxylic acid is used in the screening and evaluation of potential drug candidates. Its incorporation into compound libraries can facilitate the identification of new chemical entities with therapeutic potential.
Used in Chemical Research:
5-Methyl-2,3-pyrazinedicarboxylic acid is also used in chemical research to study the reactivity and properties of pyrazine derivatives. Understanding its behavior in various chemical reactions can provide insights into the development of new synthetic methods and the discovery of novel chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 5521-60-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,2 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5521-60:
(6*5)+(5*5)+(4*2)+(3*1)+(2*6)+(1*0)=78
78 % 10 = 8
So 5521-60-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O4/c1-3-2-8-4(6(10)11)5(9-3)7(12)13/h2H,1H3,(H,10,11)(H,12,13)
5521-60-8Relevant academic research and scientific papers
HIV INTEGRASE INHIBITORS
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Page 68, (2010/02/09)
The present invention concerns the compounds having the formula (1), N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof wherein (a) or (b); A, together with the two carbons of the phenyl ring to which it is attached forms a monocyclic aryl or a monocyclic Het2 ; R1 is hydrogen, halo, nitro, cyano, sultam, sulltim, C3-7cycloalkyl, C(=O)-R5, S(=O)y-R6, OR 7, NR8R9, C(=NR8)-R5, optionally polysubstituted C1-6alkyl, optionally polysubstituted C2-6alkenyl or optionally polysubstituted C2-6alkynyl; R 2 is hydrogen, C3-7cycloalkyl, aryl, Het1, Het2, C(=O)-R5, S(=O)Y-R6 OR7, NR8R9, C=NR8)-R5, or optionally polysubstituted C1-6alkyl, optionally polysubstituted C2-6alkenyl or optionally polysubstituted C2-6alkynyl. It further relates to their use as HIV integrase inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with other anti-retroviral agents, and to their use in assays as reference compounds or as reagents.
PREPARATION AND CONFORMATIONAL STUDY OF CIS-5-METHYL-N1,N4-DIACETYL-2-PIPERAZINE-N'-METHYL-CARBOXAMIDE
Anteunis, Marc J. O.,Hosten, Noel G. C.,Borremans, Frans A. M.,Tavernier, Dirk K.
, p. 999 - 1010 (2007/10/02)
The preparation of the racemic title compound is reported.An extensive (1)H and (13)C nmr study reveals the presence of four rotameric states about the two amide bonds (Table 4) and discloses that all four isomers possess almost identical twist-boat ring shapes characterized by an endocyclic torsion angle along the C(α)-C(β) and C(δ)-C(ε) bond of -35+/-5 deg if an L-configuration is considered.
