5521-60-8

Basic information

• Product Name: 5-Methyl-2,3-pyrazinedicarboxylic acid
• Synonyms: RARECHEM AL BO 0807;5-methyl-2,3-pyrazinedicarboxylic acid;5-METHYLPYRAZINE-2,3-DICARBOXYLIC ACID;5-Methylyrazine-2,3-dicarboxylicacid
• CAS NO: 5521-60-8
• Molecular Formula: C₇H₆N₂O₄
• Molecular Weight: 182.13
• EINECS: 226-867-7
• Mol File: 5521-60-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 174-175 °C
• Boiling Point: 438.1 °C at 760 mmHg
• Flash Point: 218.8 °C
• Appearance: /
• Density: 1.553 g/cm³
• Vapor Pressure: 1.89E-08mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• PKA: 2.03±0.10(Predicted)
• CAS DataBase Reference: 5-Methyl-2,3-pyrazinedicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-2,3-pyrazinedicarboxylic acid(5521-60-8)
• EPA Substance Registry System: 5-Methyl-2,3-pyrazinedicarboxylic acid(5521-60-8)

Safety Data

• Hazardous Substances Data: 5521-60-8(Hazardous Substances Data)

Usage

General Description

5-Methyl-2,3-pyrazinedicarboxylic acid is a chemical compound with the molecular formula C7H6N2O4. It is a derivative of pyrazine and contains a 5-methyl substituent and two carboxylic acid functional groups. 5-Methyl-2,3-pyrazinedicarboxylic acid is used in organic synthesis and can be utilized in the pharmaceutical industry to create new drugs and medications. It has the potential for various biological activities and may have applications in the development of novel treatments. The structure and properties of 5-Methyl-2,3-pyrazinedicarboxylic acid make it a valuable building block for the preparation of diverse organic compounds.

InChI:InChI=1/C7H6N2O4/c1-3-2-8-4(6(10)11)5(9-3)7(12)13/h2H,1H3,(H,10,11)(H,12,13)

Upstream product

• 7251-61-8 2-methylquinoxaline 
• 52197-12-3 5-methylpyrazine-2,3-dicarbonitrile 

Downstream Products

• 51037-30-0 acipimox 
• 123530-66-5 (E)-3-(pyrazin-2-yl)acrylic acid 
• 5521-55-1 2-methylpyrazin-5-carboxylic acid 
• 90185-89-0 6-methyl-2-piperazine-N-methyl-carboxamide 
• 7132-15-2 5-methyl-2-pyrazine-N-methyl-carboxamide 
• 5521-61-9 6-methylpyrazine-2-carboxylic acid 
• 109-08-0 2-Methylpyrazine 

Relevant articles and documents

HIV INTEGRASE INHIBITORS

The present invention concerns the compounds having the formula (1), N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof wherein (a) or (b); A, together with the two carbons of the phenyl ring to which it is attached forms a monocyclic aryl or a monocyclic Het2 ; R1 is hydrogen, halo, nitro, cyano, sultam, sulltim, C3-7cycloalkyl, C(=O)-R5, S(=O)y-R6, OR 7, NR8R9, C(=NR8)-R5, optionally polysubstituted C1-6alkyl, optionally polysubstituted C2-6alkenyl or optionally polysubstituted C2-6alkynyl; R 2 is hydrogen, C3-7cycloalkyl, aryl, Het1, Het2, C(=O)-R5, S(=O)Y-R6 OR7, NR8R9, C=NR8)-R5, or optionally polysubstituted C1-6alkyl, optionally polysubstituted C2-6alkenyl or optionally polysubstituted C2-6alkynyl. It further relates to their use as HIV integrase inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with other anti-retroviral agents, and to their use in assays as reference compounds or as reagents.

Synthesis of Pyrazinedicarboximides from Diaminomaleonitrile

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