123533-75-5Relevant academic research and scientific papers
3-PHENOXY-2-PHENYLSULPHINYLPROP-1-ENE AND 3-BROMO-2-PHENYLSULPHINYLPROP-1-ENE, SYNTHONS FOR N-ALKYLATED CYCLIC ENAMIDES.
Khan, M. Akram,Al-Saleh, Balkis
, p. 320 - 333 (2007/10/02)
2-Alkyl(and aryl)amino-2-phenylsulphinylprop-1-enes (derived from benzylamine, cyclohexylamine, and p-toluidine), underwent conjugate addition with diethyl sodiomalonate to give adducts which cyclised to give N-alkylated lactams.Thermolysis of the lactams results in regioselective elimination of benzenesulphenic acid to give N-alkylated cyclic enamides in good yields.The 3-alkyl(and aryl)amino-2-phenylsulphinylprop-1-enes were conveniently prepared by the addition of benzenesulphenic acid to 3-alkyl(and aryl)aminoprop-1-ynes, and by reaction of 3-bromo- and 3-phenoxy-2-phenylsulphinylprop-1-ene with the appropriate amine.
