123534-48-5Relevant academic research and scientific papers
Microwave-assisted three-component coupling-addition-SNAr (CASNAR) sequences to annelated 4H-thiopyran-4-ones
Willy, Benjamin,Frank, Walter,Mueller, Thomas J. J.
supporting information; experimental part, p. 90 - 95 (2010/04/26)
A whole family of annelated 4H-thiopyran-4-ones as the core structural unit was readily synthesized in good yields by a microwave-assisted coupling-addition-SNAr (CASNAR) sequence starting from readily available (het)aroyl chlorides, alkynes and sodium sulfide nonahydrate in a consecutive one-pot three-component reaction. All representatives display a pronounced halochromicity of the absorption bands upon protonation. According to DFT calculations, the electronic ground state of the annelated 4H-thiopyran-4-ones possess a considerable zwitterionic character. The Royal Society of Chemistry 2010.
A novel consecutive three-component coupling-addition-SNAr (CASNAR) synthesis of 4H-thiochromen-4-ones
Willy, Benjamin,Müller, Thomas J. J.
experimental part, p. 1255 - 1260 (2009/08/14)
4H-Thiochromen-4-ones and 4H-thiopyrano[2,3-b]pyridin-4-ones are readily synthesized in good yields by a consecutive one-pot, three-component coupling-addition-SNAr (CASNAR) sequence starting from aroyl chlorides, alkynes, and sodium sulfide no
A Facile and Concise Synthesis of 2-Alkyl- and 2-Aryl-4-oxo-4H-thiopyranopyridines
Couture, Axel,Grandclaudon, Pierre,Huguerre, Eric
, p. 456 - 457 (2007/10/02)
2-Alkyl- and 2-aryl-4-oxo-4H-thiopyranopyridine can be conveniently prepared by reacting the appropriate aromatic and aliphatic O-ethyl thiocarboxylates with the sodium derivative of various alkyl 3-(2-bromopyridyl) ketones.
