84199-61-1

Basic information

• Product Name: 3-Acetyl-2-bromopyridine
• Synonyms: 3-ACETYL-2-BROMOPYRIDINE;1-(2-BROMO-PYRIDIN-3-YL)-ETHANONE;Ethanone, 1-(2-bromo-3-pyridinyl)-;1-(2-broMopyridin-3-yl)ethan-1-one;1-(2-Bromo-3-pyridinyl)ethanone;3-(2-Bromopyridyl) methyl ketone
• CAS NO: 84199-61-1
• Molecular Formula: C₇H₆BrNO
• Molecular Weight: 200.03
• Product Categories: Heterocycle-Pyridine series
• Mol File: 84199-61-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 292.224oC at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.552 g/mL at 25 °C
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: n20/D1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.01±0.10(Predicted)
• CAS DataBase Reference: 3-Acetyl-2-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetyl-2-bromopyridine(84199-61-1)
• EPA Substance Registry System: 3-Acetyl-2-bromopyridine(84199-61-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 1
• Hazardous Substances Data: 84199-61-1(Hazardous Substances Data)

Usage

Uses

3-Acetyl-2-bromopyridine is a chemical reagent used in nonquaternary reactivators of GF-inhibited human acetylcholinesterase. Also used in the synthesis of HIV-1 reverse transriptase inhibitors.

InChI:InChI=1/C7H6BrNO/c1-5(10)6-3-2-4-9-7(6)8/h2-4H,1H3

Upstream product

• 75-16-1 methylmagnesium bromide 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 109-04-6 2-bromo-pyridine 
• 84199-57-5 1-(2′-bromo-3′-pyridyl)ethan-1-ol 

Downstream Products

• 123534-49-6 2-(4-chlorophenyl)-4H-thiopyrano[2,3-b]pyridin-4-one 
• 1350844-43-7 1-(2-((3-(trifluoromethyl)phenyl)ethynyl)pyridin-3-yl)ethanone 
• 1350844-61-9 1-(2-((1-hydroxycyclohexyl)ethynyl)pyridin-3-yl)ethanone 
• 1350845-19-0 5-methyl-7-p-tolyl-1,6-naphthyridine 
• 71109-34-7 3-methyl-1,2-thiazolo<5,4-b>pyridine 
• 942274-97-7 methyl 2-(3-acetylpyridin-2-yl)benzoate 
• 13603-10-6 (+/–)-3-ethylpiperidine 
• 84199-57-5 1-(2′-bromo-3′-pyridyl)ethan-1-ol 

Relevant articles and documents

Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions

A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta

One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols Using Br?nsted Acid and Palladium Catalysis

A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asymmetric synthesis of 3-methyleneindanes bearing a tertiary alcohol center. Br?nsted acid-catalyzed allylboration with a chiral BINOL derivative was followed by a palladium-catalyzed Mizoroki-Heck cyclization, resulting in selective formation of the exo-alkene. This novel protocol provides a concise and scalable approach to 1-alkyl-3-methyleneindan-1-ols in high enantiomeric ratios (up to 96:4 er). The potential of these compounds as chiral building blocks was demonstrated with efficient transformation to optically active diol and amino alcohol scaffolds.

Silver-catalysed intramolecular cyclisation of 2-alkynylacetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia

Silver-catalysed/microwave-assisted domino reactions of 2-alkynyl-acetophenones and 3-acetyl-2-alkynylpyridines in the presence of ammonia are widely described. In most cases the reaction give a mixture of the imino- and carbo-cyclisation products, with a