123536-15-2

Basic information

• Product Name: (R)-quinuclidin-3-aMine
• Synonyms: (R)-quinuclidin-3-aMine;(R)-1-Aza-bicyclo[2.2.2]oct-3-ylamine;1-Azabicyclo[2.2.2]octan-3-amine, (R)-
• CAS NO: 123536-15-2
• Molecular Formula: C₇H₁₄N₂
• Molecular Weight: 126.19946
• Mol File: 123536-15-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 165.9±8.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.58±0.33(Predicted)
• CAS DataBase Reference: (R)-quinuclidin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-quinuclidin-3-aMine(123536-15-2)
• EPA Substance Registry System: (R)-quinuclidin-3-aMine(123536-15-2)

Safety Data

• Hazardous Substances Data: 123536-15-2(Hazardous Substances Data)

Usage

General Description

(R)-quinuclidin-3-amine, often recognized as a bicycic aliphatic amine, is a chemical compound mostly used in the synthesis of various pharmaceuticals. Its primary feature is its rigid bicyclic structure consisting of one nitrogen atom and six carbon atoms in a four-five ring junction. (R)-quinuclidin-3-aMine technically is a key building block in the production of numerous therapeutic drugs or medicines. Purity, stability, molecular weight, and solubility are some crucial properties to ensure its effectiveness in chemical synthesis. For safety, it needs to be handled carefully due to its corrosive and harmful nature when in contact with skin or if inhaled.

Upstream product

• 16205-47-3 7-methyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 123194-01-4 3-amino-1-azabicyclo<2.2.2>octane-3-carbonitrile 

Downstream Products

• 197860-59-6 6-chloro-7-nitro-1H-benzoimidazole-4-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide 
• 255064-05-2 6-bromo-7-nitro-1H-benzoimidazole-4-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide 
• 155778-25-9 (R)-3-benzamidoquinuclidine 

Relevant articles and documents

Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones

We have developed a catalytic system based on bianthrylbis(thiourea) for the asymmetric Henry reaction of fluoroketones and nitroalkanes that resulted from the screening of a library containing 31 chiral non-racemic organocatalysts. The corresponding adducts were isolated in up to 6 times shorter reaction time in comparison with the previously published organocatalysts. High levels of stereocontrol have been generally observed, with measured product enantiomeric excesses up to 97% and diastereomeric ratio 3:2 (anti/syn). The above-mentioned catalysts have been successfully applied to the total asymmetric synthesis of CF3-tethered (S)-halostachines, which has proved that this method constitutes an easy entry to similar enantiopure compounds.

Pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives and their pharmaceutical use

Described herein are pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives represented by the following formula (I): STR1 wherein R 1 and R 2 individually mean a hydrogen atom or a lower alkyl group, R 3 denotes an azabicyclo group containing a tertiary nitrogen atom, and Y stands for --O-- or --NH--, or salts thereof. Their preparation process and serotonin receptor antagonists containing them as active ingredients are also described.

Fused imidazoheterocyclic compounds and pharmaceutical compositions

Imidazoheterocyclic compounds having the formula: STR1 wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen, loweralkyl, hydroxy, loweralkoxy, diloweralkylamino or nitro; Ar i