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• 479682-81-0 1,4-dihydroxy-1-(2'-methoxyphenyl)but-2-yne 

Relevant academic research and scientific papers

A novel iodine-promoted tandem cyclization: An efficient synthesis of substituted 3,4-diiodoheterocyclic compounds

(Figure Presented) Iodine sets allenes ringing: A novel iodine-promoted tandem cyclization reaction of but-2-yne-1,4-diol and 4aminobut-2-yn-l-ol derivatives leading to substituted 3, 4-diiodoheterocyclic compounds has been developed (see scheme). In this

Synthesis of five- and six-membered dihalogenated heterocyclic compounds by electrophile-triggered cyclization

Highly substituted dihalogenated dihydrofurans, dihydropyrroles, and dihydro-2H-pyrans bearing alkyl, vinyl, aryl, and heteroaryl moieties can be prepared in good to excellent yields (up to 99%) by allowing 1,4-butyne-diol, 4-aminobut-2-yn-1-ol, and pent-2-yne-1,5-diol derivatives to react with different electrophiles (I2, IBr, and ICl) at room temperature. Both halogen atoms generated from electrophiles were used effectively. The resulting halides can be further exploited by using palladium-catalyzed coupling reactions. The presence of trace amount of water is essential for this electrophilic cyclization.