123539-91-3Relevant academic research and scientific papers
The bioavailability of injectable, amorphous form of aztreonam
Sasinowska-Motyl, Malgorzata,Gumulka, Witold,Filipek, Marian,Oszczapowicz, Irena,Sikora, Adam,Szczesna, Iwona
, p. 475 - 480 (2007/10/03)
Amorphos injectable form of aztreonam (BIOKTAM) was prepared. It was shown that after intramuscular or intravenous administration there are not any considerable differences in the bioavailability of aztreonam from BIOKTAM and of the drug from AZACTAM.
MONOBACTAMS: RING ACTIVATING N-1-SUBSTITUENTS IN MONOCYCLIC &β-LACTAM ANTIBIOTICS
Slusarchyk, William A.,Dejneka, Tamara,Gordon, Eric M.,Weaver, Eugene R.,Koster, William H.
, p. 191 - 210 (2007/10/02)
Several alternatives to the sulfonate residue in the naturally-occurring monobactams, 3-acylamino-2-oxoazetidine-1-sulfonates, provide new monobactams having potent activity against aerobic gram-negative bacteria.The monobactams compared here include: (a) those where the anionic activating group (sulfonate or phosphonate(-inate)) is attached to the β-lactam nitrogen, and (b) those where an oxygen atom is interposed between the acidic group and the β-lactam nitrogen, i.e. sulfate and phosphate(-onate) groups.Chemical and biological relationships between these classesof monobactams are presented.
