1235394-84-9Relevant academic research and scientific papers
Synthesis of All- L cyclic tetrapeptides using pseudoprolines as removable turn inducers
Fairweather, Kelly A.,Sayyadi, Nima,Luck, Ian J.,Clegg, Jack K.,Jolliffe, Katrina A.
, p. 3136 - 3139 (2010)
(Figure Presented) Cyclic tetrapeptides have generated great interest because of their broad-ranging biological properties. In order to synthesize these highly strained 12-membered cyclic compounds, a cyclization strategy using pseudoprolines as removable turn inducers has been developed. The pseudoproline derivatives induce a cisoid amide bond in the linear peptide backbone which facilitates cyclization. After cyclization, the turn inducers can be readily removed to afford cyclic tetrapeptides containing serine or threonine residues.
