1235442-56-4Relevant academic research and scientific papers
Highly Stereoselective Synthesis of syn-1,3-Diols through a Sequential Titanium-Mediated Aldol Reaction and LiBH4 Reduction
Esteve, Judit,Matas, Sonia,Pellicena, Miquel,Velasco, Javier,Romea, Pedro,Urpi, Felix,Font-Bardia, Merce
, p. 3146 - 3151 (2010)
A sequential transformation based on a titanium-mediated aldol reaction from chiral α-tert-butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH4 provides a straightforward, access to syn-1,3-diols. These diols, containing up to three new stereocentres, can be easily isolated in high yields after a simple work-up without any additional oxidative treatment, which confers to this procedure an appealing position to prepare stereoselectively such sort of structures.
