123545-82-4Relevant academic research and scientific papers
New anionic glycophospholipids with two perfluorocarbon or two hydrocarbon or mixed hydrophobic chains
Guillod, Frederic,Greiner, Jacques,Riess, Jean G.
, p. 149 - 162 (1995)
Novel amphiphilic anionic sugar phosphates esterified by various hydrophobic double-chain tails were synthesized. They differ primarily by the design of their hydrophobic tail. Amphiphile 12a derives from phosphogalactose and has two perfluoroalkylated hy
Detection of apoptosis by PET/CT with the diethyl ester of [ 18F]ML-10 and fluorescence imaging with a dansyl analogue
Kadirvel, Manikandan,Fairclough, Michael,Cawthorne, Christopher,Rowling, Emily J.,Babur, Muhammad,McMahon, Adam,Birkket, Paul,Smigova, Alison,Freeman, Sally,Williams, Kaye J.,Brown, Gavin
, p. 341 - 349 (2014/01/17)
The diethyl ester of [18F]ML-10 is a small molecule apoptotic PET probe for cancer studies. Here we report a novel multi-step synthesis of the diethyl ester of ML-10 in excellent yields via fluorination using Xtal-Fluor-E. In addition, a one-pot radiosynthesis of the diethyl ester of [ 18F]ML-10 from nucleophilic [18F]fluoride was completed in 23% radiochemical yield (decay corrected). The radiochemical purity of the product was ≥99%. The diethyl ester of [18F]ML-10 was used in vivo to detect apoptosis in the testes of mice. In parallel studies, the dansyl-ML-10 diethyl ester was prepared and used to detect apoptotic cells in an in vitro cell based assay.
Polystyrene-supported GaCl3: A new, highly efficient and recyclable heterogeneous Lewis acid catalyst for tetrahydropyranylation of alcohols and phenols
Rahmatpour, Ali
, p. 66 - 71,6 (2012/12/11)
A new, simple and highly chemoselective method for tetrahydropyranylation of alcohols and phenols with 3,4-dihydro-2H-pyran (DHP) in the presence of polystyrene-supported gallium trichloride (PS/GaCl3) as a highly active and reusable heterogeneous Lewis acid catalyst at room temperature is presented.
Synthetic studies directed toward kaitocephalin: A highly stereocontrolled route to the right-hand pyrrolidine core
Takahashi, Keisuke,Haraguchi, Natsumi,Ishihara, Jun,Hatakeyama, Susumi
, p. 671 - 674 (2008/12/20)
A highly stereocontrolled method for the construction of the right-hand segment of kaitocephalin, an antagonist of AMPA/KA and NMDA glutamate receptors, has been developed employing palladium-catalyzed cyclization of an oxiranylacrylate at the quaternary
A highly efficient synthetic protocol for tetrahydropyranylation/ depyranylation of alcohols and phenols
Khan, Abu T.,Ghosh, Subrata,Choudhury, Lokman H.
, p. 4891 - 4896 (2007/10/03)
Bismuth(III) nitrate pentahydrate [Bi(NO3)3· 5H2O] is found to be an effective catalyst for both tetrahydropyranylation and depyranylation of alcohols and phenols. Some of the major advantages of this protocol are: non-aqueous workup, good yields, the involvement of a less-expensive and nontoxic catalyst, and compatibility in the presence of a large number of other protecting groups. Notably, isopropylidene, benzylidene, and thioacetal groups are also unaffected under the experimental conditions. Remarkably, a selective mono-protection of diols and primary alcohols can be achieved chemoselectively by employing the same catalyst. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
Tetrabutylammonium tribromide (TBATB)-promoted tetrahydropyranylation/depyranylation of alcohols
Naik, Sarala,Gopinath, Rangam,Patel, Bhisma K
, p. 7679 - 7681 (2007/10/03)
Alcohols are tetrahydropyranylated rapidly in high yields in the presence of a catalytic amount of TBATB in dichloromethane at room temperature. Depyranylation to their parent alcohol is achieved in quantitative yields by merely changing the solvent to methanol.
