1216897-16-3

Usage

Uses

Used in Pharmaceutical Development:
2-(5-fluoropentyl)-2-methylmalonic acid is used as a cannabinoid receptor ligand for the development of new pharmaceuticals targeting the CB1 and CB2 receptors. Its interaction with these receptors can lead to therapeutic effects like pain relief, appetite stimulation, and mood alteration, making it a valuable compound for further study and exploration in the field of pharmacology.
Used in Research and Experimentation:
In the scientific community, 2-(5-fluoropentyl)-2-methylmalonic acid serves as an important tool in research and experimentation. Its role as a potent agonist for CB1 and CB2 receptors allows researchers to study the mechanisms of action and potential applications of these receptors in various physiological and pathological conditions. This contributes to a deeper understanding of the endocannabinoid system and its role in human health and disease.

Upstream product

• 1415564-81-6 di-tert-butyl 2-(5-fluoropentyl)-2-methylmalonate 
• 1381879-32-8 di-tert-butyl 2-(5-hydroxypentyl)-2-methylmalonate 
• 1528636-73-8 di-tert-butyl 2-methyl-2-(5-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)malonate 
• 1528636-72-7 di-tert-butyl 2-(5-((tetrahydro-2H-pyran-2-yl)oxy)pentyl)malonate 
• 123545-82-4 1-<5-<2-(tetrahydropyranyloxy)>pentyl> p-toluenesulfonate 
• 95769-37-2 5-hydroxypentyl p-toluenesulfonate 
• 111-29-5 1 ,5-pentanediol 
• 1443626-98-9 diethyl 2-methyl-2-(5-(tosyloxy)pentyl)malonate 
• 111-24-0 1,5-dibromo-pentane 
• 174583-20-1 diethyl 2-(5-bromopentyl)-2-methylmalonate 

Relevant academic research and scientific papers

Detection of apoptosis by PET/CT with the diethyl ester of [ 18F]ML-10 and fluorescence imaging with a dansyl analogue

The diethyl ester of [18F]ML-10 is a small molecule apoptotic PET probe for cancer studies. Here we report a novel multi-step synthesis of the diethyl ester of ML-10 in excellent yields via fluorination using Xtal-Fluor-E. In addition, a one-pot radiosynthesis of the diethyl ester of [ 18F]ML-10 from nucleophilic [18F]fluoride was completed in 23% radiochemical yield (decay corrected). The radiochemical purity of the product was ≥99%. The diethyl ester of [18F]ML-10 was used in vivo to detect apoptosis in the testes of mice. In parallel studies, the dansyl-ML-10 diethyl ester was prepared and used to detect apoptotic cells in an in vitro cell based assay.

Microfluidic radiosynthesis and biodistribution of [18F] 2-(5-fluoro-pentyl)-2-methyl malonic acid

Microfluidics technology has emerged as a powerful tool for the radiosynthesis of positron emission tomography (PET) and single-photon emission computed tomography radiolabeled compounds. In this work, we have exploited a continuous flow microfluidic system (Advion, Inc., USA) for the [ 18F]-fluorine radiolabeling of the malonic acid derivative, [ 18F] 2-(5-fluoro-pentyl)-2-methyl malonic acid ([18F]- FPMA), also known as [18F]-ML-10, a radiotracer proposed as a potential apoptosis PET imaging agent. The radiosynthesis was developed using a new tosylated precursor. Radiofluorination was initially optimized by manual synthesis and served as a basis to optimize reaction parameters for the microfluidic radiosynthesis. Under optimized conditions, radio-thin-layer chromatography analysis showed 79% [18F]-fluorine incorporation prior to hydrolysis and purification. Following hydrolysis, the [18F]-FPMA was purified by C18 Sep-Pak, and the final product was analyzed by radio-HPLC (high-performance liquid chromatography). This resulted in a decay-corrected 60% radiochemical yield and ≥98% radiochemical purity. Biodistribution data demonstrated rapid blood clearance with less than 2% of intact [ 18F]-FPMA radioactivity remaining in the circulation 60 min post-injection. Copyright