1235455-75-0Relevant academic research and scientific papers
Synthesis and cytotoxic activity of heterocyclization products of 1,1-dicyano-2-hetaryl-2-trifluoromethylethylenes
Pavlova,Shidlovskii,Gusev,Peregudov,Bulychev,Chkanikova
, p. 162 - 176 (2011/01/09)
Methods for the synthesis of novel fluorinated compounds by reaction of 1,1-dicyano-2-hetaryl-2-trifluoromethylethylenes with a variety of nitrogen heterocycles have been developed. Cyctotoxicity of the obtained organofluorine heterocycles were studied in vitro at the U.S. National Cancer Institute (NCI) in the framework of the International Program for Development of Effective Antitumor Drugs. Cytotoxic activity in the series of fluorinated pyrazolo[1,5-a]pyrimidines has been observed for the first time, this strongly depending on the nature and position of the substituents.
