651-70-7

Basic information

• Product Name: 2-(TRIFLUOROACETYL)THIOPHENE
• Synonyms: 2-(TRIFLUOROACETYL)THIOPHENE;2,2,2-TRIFLUORO-1-THIOPHEN-2-YL-ETHANONE;2,2,2-TRIFLUORO-1-(2-THIENYL)ETHANONE;Ethanone, 2,2,2-trifluoro-1-(2-thienyl)- (9CI);1-(Thien-2-yl)-2,2,2-trifluoroethan-1-one;2-Thienyl trifluoromethyl ketone;2,2,2-trifluoro-1-(thiophen-2-yl)ethan-1-one
• CAS NO: 651-70-7
• Molecular Formula: C₆H₃F₃OS
• Molecular Weight: 180.15
• Product Categories: ACETYLHALIDE;Carbonyl Compounds;Heterocycles;Building Blocks;Heterocyclic Building Blocks;Thiophenes
• Mol File: 651-70-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 163-165 °C(lit.)
• Flash Point: 138 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.403 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.573mmHg at 25°C
• Refractive Index: n20/D 1.486(lit.)
• Storage Temp.: 2-8°C(protect from light)
• BRN: 1309208
• CAS DataBase Reference: 2-(TRIFLUOROACETYL)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROACETYL)THIOPHENE(651-70-7)
• EPA Substance Registry System: 2-(TRIFLUOROACETYL)THIOPHENE(651-70-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 651-70-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 2003, 1991 DOI: 10.1016/S0040-4039(00)78892-7

InChI:InChI=1/C6H3F3OS/c7-6(8,9)5(10)4-2-1-3-11-4/h1-3H

Upstream product

• 188290-36-0 thiophene 
• 1547-87-1 N,N-dimethyl-2,2,2-trifluoroacetamide 

Downstream Products

• 1316854-94-0 cyclohexyl 5-(thiophen-2-yl)-5-(trifluoromethyl)-4,5-dihydrofuran-2-carboxylate 
• 1366284-65-2 N-(1-(4-chlorophenyl)-2,2-difluoro-3-oxo-3-(thiophen-2-yl)propyl)benzohydrazide 
• 1369922-85-9 phenyl 4,4,4-trifluoro-3-hydroxy-3-(thiophen-2-yl)butanoate 
• 1356140-84-5 benzylidene-1-(thien-2-yl)-2,2,2-trifluoroethylamine 
• 1353637-25-8 (2E,3Z)-methyl 2-benzylidene-5,5,5-trifluoro-4-(thiophen-2-yl)pent-3-enoate 
• 1334288-01-5 (R)-4-methoxy-N-(2,2,2-trifluoro-1-(thiophen-2-yl)ethyl)aniline 
• 313353-93-4 4-methoxy-N-(2,2,2-trifluoro-1-(thiophen-2-yl)ethylidene)aniline 
• 1235455-75-0 C₁₉H₁₂ClF₃N₄OS 
• 1235455-69-2 6-amino-5-cyano-3-methyl-4-(2-thienyl)-4-trifluoromethyl-1-(4-trifluoromethylphenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine 
• 1235455-68-1 C₁₉H₁₄F₃N₅OS 
• 1235455-67-0 C₁₈H₁₁ClF₃N₅S 
• 959270-73-6 C₁₆H₁₁F₃N₄S 
• 1235455-82-9 C₂₀H₁₈F₃N₃S 

Relevant articles and documents

A Convenient Preparation of Aryltrifluoromethylketones

The reaction of aryllithium reagents prepared by halogen metal exchange or direct metallation with α,α,α-trifluoro-N,N-dimethylacetamide give the corresponding aryltrifluoromethylketones in good yield.