1235461-07-0Relevant academic research and scientific papers
The design, synthesis, and antiviral activity of 4′-azidocytidine analogues against hepatitis C virus replication: The discovery of 4′-azidoarabinocytidine
Smith, David B.,Kalayanov, Genadiy,Sund, Christian,Winqvist, Anna,Pinho, Pedro,Maltseva, Tatiana,Morisson, Veronique,Leveque, Vincent,Rajyaguru, Sonal,Pogam, Sophie Le,Najera, Isabel,Benkestock, Kurt,Zhou, Xiao-Xiong,Maag, Hans,Cammack, Nick,Martin, Joseph A.,Swallow, Steven,Johansson, Nils Gunnar,Klumpp, Klaus,Smith, Mark
, p. 219 - 223 (2009)
4′-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of several der
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4′-azidocytidine against hepatitis C virus replication: The discovery of 4′-azido-2′-deoxy-2′-fluorocytidine and 4′-azido-2′-dideoxy-2′,2′-difluorocytidine
Smith, David B.,Kalayanov, Genadiy,Sund, Christian,Winqvist, Anna,Maltseva, Tatiana,Leveque, Vincent J.-P.,Rajyaguru, Sonal,Le Pogam, Sophie,Najera, Isabel,Benkestock, Kurt,Zhou, Xiao-Xiong,Kaiser, Ann C.,Maag, Hans,Cammack, Nick,Martin, Joseph A.,Swallow, Steven,Johansson, Nils Gunnar,Klumpp, Klaus,Smith, Mark
experimental part, p. 2971 - 2978 (2010/02/28)
The discovery of 4′-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC50 = 1.28 μM), the RNA polymerase encoded by hepatitis C virus (HCV), has led to the
PROCESSES FOR PREPARING 4’AZIDO NUCLEOSIDE DERIVATIVES
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Page 25-26, (2010/02/10)
A process for the preparation of a 4’-azido-2’,3’,5’-triacyl-nucleoside compound (I;B=B1; R1 is R1aCO-and R2 is R2aCO-) or a 4’-azidonucleoside compounds (I; B is B1 or B2 and R1 and R2 are
