1235489-84-5Relevant academic research and scientific papers
Selectivity of N-aroyl-N′-arylthioureas towards 2-(1,3-Dioxo-1H- inden-2(3H)-ylidene)malononitrile. New synthesis of (Z)-N-((E)-4-amino-1-aryl-5- cyano-6-oxo-1H-indeno[1,2-d][1,3]-thiazepin-2(6H)-ylidene)-4-arylamides of antitumor and antioxidant activities
Aly, Ashraf A.,Brown, Alan B.,Ramadan, Mohamed,Abdel-Aziz, Mohamed,Abuo-Rahma, Gamal El-Din A. A.,Radwan, Mohamed F.,Gamal-Eldeend, Amira M.
, p. 503 - 508 (2010)
The reaction between N-aroyl-N′-arylthioureas with 2-(1,3-dioxoindan-2-ylidene)malononitrile furnished indeno[1,2-d][1,3] thiazepines in 70-85% yields. The mechanism of the products' formation is discussed. Some of the products showed effective antitumor and antioxidant activities. The results revealed that compound indenothiazepine derivative showed a high inhibition of the cell growth of Hep-G2 cells is compared with the growth of untreated control cells, as concluded from their low IC50 value 21.73 μM. On the other hand, two indenothiazepine derivatives have an effective antioxidant activity with SC50 values of 62.5 mM and 87.4 mM, respectively.
