1235514-53-0Relevant academic research and scientific papers
Interplay between the ribosomal tunnel, nascent chain, and macrolides influences drug inhibition
Starosta, Agata L.,Karpenko, Viktoriya V.,Shishkina, Anna V.,Mikolajka, Aleksandra,Sumbatyan, Natalia V.,Schluenzen, Frank,Korshunova, Galina A.,Bogdanov, Alexey A.,Wilson, Daniel N.
, p. 504 - 514 (2010)
Accumulating evidence suggests that, during translation, nascent chains can form specific interactions with ribosomal exit tunnel to regulate translation and promote initial folding events. The clinically important macrolide antibiotics bind within the ex
Amino acid and peptide derivatives of the tylosin family of macrolide antibiotics modified by aldehyde function
Sumbatyan,Kuznetsova,Karpenko,Fedorova,Chertkov,Korshunova,Bogdanov
experimental part, p. 245 - 256 (2011/09/13)
Fourteen new functionally active amino acid and peptide derivatives of the antibiotics tylosin, desmycosin, and 5-O-mycaminosyltylonolide were synthesized in order to study the interaction of the growing polypeptide chain with the ribosomal tunnel. The co
