1235544-19-0Relevant academic research and scientific papers
Protein chemical synthesis by ligation of peptide hydrazides
Fang, Ge-Min,Li, Yi-Ming,Shen, Fei,Huang, Yi-Chao,Li, Jia-Bin,Lin, Yun,Cui, Hong-Kui,Liu, Lei
supporting information; experimental part, p. 7645 - 7649 (2011/10/02)
pH determines selectivity: The ligation of peptide hydrazides is a new method for protein chemical synthesis that is complementary to native chemical ligation. Peptide hydrazides may be the long-sought reagent equivalent to a "thioester synthon", one that
Chemical protein synthesis by kinetically controlled ligation of peptide O-esters
Zheng, Ji-Shen,Cui, Hong-Kui,Fang, Ge-Min,Xi, Wei-An,Liu, Lei
scheme or table, p. 511 - 515 (2010/12/25)
(Chemical Equation Presented) Designer peptides: A large reactivity difference was observed between two peptide O-esters that can undergo peptide ligation through an situ O-to-S acyl shift. This observation allowed the designed of "one-pot" N-to-C sequential peptide fragment condensation through kinetically controlled ligation with more readily accessible peptide O-esters.
