1235649-95-2Relevant academic research and scientific papers
Pd-catalyzed decarboxylative cross-coupling of sodium pyrimidinecarboxylates with (hetero)aryl bromides
Wang, Shengqiang,Lu, Hongtao,Zou, Dapeng,Wu, Yangjie,Li, Jingya,Wu, Yusheng,Zou, Dapeng,Wu, Yusheng,Li, Jingya
supporting information, p. 2723 - 2726 (2017/06/23)
A straightforward method for the synthesis of functionalized 4- or 5-(hetero)arylpyrimidines via decarboxylative cross-coupling reaction from readily available pyrimidine-4- and pyrimidine-5-carboxylates was described. In the presence of dual-catalyst system of Pd(PPh3)4/Cu2O, the reaction proceeds smoothly, tolerates a variety of functional groups, and provides easy access to the synthesis of different (hetero)arylpyrimidines compounds.
Fast and green one-pot multicomponent synthesis of a library of pyrrolo[1,2-c] pyrimidines under microwave irradiation
Georgescu, Emilian,Georgescu, Florentina,Draghici, Constantin,Cristian, Liliana,Popa, Marcel Mirel,Dumitrascu, Florea
, p. 851 - 857 (2014/03/21)
A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
