302912-52-3Relevant academic research and scientific papers
Fast and green one-pot multicomponent synthesis of a library of pyrrolo[1,2-c] pyrimidines under microwave irradiation
Georgescu, Emilian,Georgescu, Florentina,Draghici, Constantin,Cristian, Liliana,Popa, Marcel Mirel,Dumitrascu, Florea
, p. 851 - 857 (2014/03/21)
A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
