123565-82-2

Upstream product

• 123542-48-3 ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate 
• 105-56-6 ethyl 2-cyanoacetate 
• 18794-95-1 3-oxo-2-(2-(4-methoxyphenyl)hydrazono)butanoic acid ethyl ester 
• 104-94-9 4-methoxy-aniline 
• 89516-30-3 1-cyano-1,3-diethoxycarbonyl-2-methyl-1-propene 

Downstream Products

• 128639-59-8 4-Cyano-5-methyl-2-(4'-methoxyphenyl)pyridazin-3(2H)-one 
• 1443744-74-8 C₁₅H₁₅FN₄O₂S 
• 1443745-74-1 C₂₀H₂₃FN₄O₄S 
• 1443745-73-0 C₂₀H₂₃FN₄O₄ 
• 222164-49-0 [5-cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]carbamic acid tert-butyl ester 
• 1443744-73-7 (S)-7-amino-4-(3-fluoropyrrolidine-1-carbonyl)-2-(4-methoxyphenyl)thieno[3,4-d]pyridazin-1(2H)-one 
• 1443744-64-6 C₂₁H₂₃FN₄O₃S 
• 1443744-72-6 (R)-7-amino-4-(3-fluoropyrrolidine-1-carbonyl)-2-(4-methoxyphenyl)thieno[3,4-d]pyridazin-1(2H)-one 
• 1443744-71-5 5-amino-N-(2-fluoroethyl)-3-(4-methoxyphenyl)-4-oxo-3,4-dihydrothienor3,4-dlpyridazine-1-carboxamide 
• 1443744-70-4 C₂₈H₂₉FN₆O₅S 
• 1443745-34-3 C₂₃H₂₁FN₆O₃S 
• 1443745-72-9 C₁₈H₂₀N₄O₃S 
• 1443745-71-8 C₂₃H₂₈N₄O₅S 
• 1443745-70-7 C₂₀H₂₁N₃O₆S 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY

Pyridazinone compounds of Formula I: (I) wherein: R' is alkyl or Ar, optionally substituted with at least one alkyl, halo? gen, hydroxyl, alkoxy, haloalkoxy, acid, ester, amino, nitro, amide, or alkoxyhalo; 2 R is independently alkyi, alkynyl, ester, amino, amide, acid, aryl, heteroaryl, aminoalkyl, -C(=0)alkyl, -C(=0)aryl, -C(=0)heteroaryl, -C(=0)heterocycloalkyl, - C(=0)heterocycloalkylAr, -C(=0)(CH2)nhalo, -C(=0)(CH2)nheterocyclyl, or -SC^Ar, optionally substituted with at least one alkyi, alkylhalo, halogen, nitro, aryl, heteroaryl, or heteroaryl(CH2)nhalo; R 3 and R4 are independently hydrogen, alkyi, alkenyl, alkynyl, aryl, heteroaryl; Ar is an aryl, heteroaryl, cycloalkyl, heterocycloalkyl group; n is an integer from 0-10; or a radiolabeled derivative thereof. The compounds are useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.

2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists

A pharmacophore-based screen identified 32 compounds including ethyl 5-amino-3-(4-tert-butylphenyl)-4-oxo-3,4-dihydrothieno[3,4-d] pyridazine-1-carboxylate (8) as a new allosteric modulator of the adenosine A1 receptor (A1AR). On the basis of this lead, various derivatives were prepared and evaluated for activity at the human A 1AR. A number of the test compounds allosterically stabilized agonist-receptor-G protein ternary complexes in dissociation kinetic assays, but were found to be more potent as antagonists in subsequent functional assays of ERK1/2 phosphorylation. Additional experiments on the most potent antagonist, 13b, investigating A1AR-mediated [35S]GTPγS binding and [3H]CCPA equilibrium binding confirmed its antagonistic mode of action and also identified inverse agonism. This study has thus identified a new class of A1AR antagonists that can also recognize the receptor's allosteric site with lower potency.

STUDIES ON ALKYLHETEROAROMATIC COMPOUNDS: NEW SYNTHESES OF 1,3,4-OXADIAZOLE, OXADIAZOLOPYRIDINE, 1,3,4-THIADIAZOLE, THIADIAZOLOPYRIDINE, PHTHALAZINE AND THIENOPYRIDAZINE DERIVATIVES.

Ethyl 5-phenyl-1,3,4-oxadiazol-2-ylacetate (3a) could be prepared via condensation of ethyl 3-amino-3-ethoxyprop-2-enoate (1) with benzoylhydrazine.This product coupled with aromatic diazonium salts to yield arylhydrazones 4a,b.Compound 3a was converted i

α,β-Unsaturated Nitriles in Heterocyclic Synthesis: Synthesis of Several Arylpyridine and Arylpyridazine Derivatives

Several new azabiaryls and diazabiaryls were synthesized utilizing readily obtainable α,β-unsaturated nitriles.

Studies with Alkylheteroaromatic ?-Deficient Compounds: Novel Synthesis of Thienopyridazines and Phthalazines

Ethyl 1-aryl-5-cyano-1,6-dihydro-4-methyl-6-oxo-3-pyridazinecarboxylates 1 react with elemental sulphur in ethanolic basic solutions to yield thienopyridazines 2.Compounds 2 readily react with electron-deficient olefins to yield phthalazines.