18794-95-1

Basic information

• Product Name: Butanoic acid, 2-[2-(2-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester
• Synonyms: Butanoic acid, 2-[2-(2-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester
• CAS NO: 18794-95-1
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 264.27714
• Mol File: 18794-95-1.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanoic acid, 2-[2-(2-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[2-(2-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester(18794-95-1)
• EPA Substance Registry System: Butanoic acid, 2-[2-(2-Methoxyphenyl)hydrazinylidene]-3-oxo-, ethyl ester(18794-95-1)

Safety Data

• Hazardous Substances Data: 18794-95-1(Hazardous Substances Data)

Upstream product

• 4346-59-2 para-methoxyphenyldiazonium chloride 
• 141-97-9 ethyl acetoacetate 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 123565-82-2 ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate 
• 1447667-19-7 1-((3-(4-chlorophenyl)-1H-pyrazole-5-yl)carbonyl)-3-methyl-4-(2-(4-methoxyphenyl)hydrazono)-1H-pyrazol-5(4H)-one 
• 1346005-96-6 C₂₂H₂₀N₆O₂S 
• 1443744-74-8 C₁₅H₁₅FN₄O₂S 
• 1443745-74-1 C₂₀H₂₃FN₄O₄S 
• 1443745-73-0 C₂₀H₂₃FN₄O₄ 
• 222164-49-0 [5-cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]carbamic acid tert-butyl ester 
• 1443744-73-7 (S)-7-amino-4-(3-fluoropyrrolidine-1-carbonyl)-2-(4-methoxyphenyl)thieno[3,4-d]pyridazin-1(2H)-one 
• 1443744-64-6 C₂₁H₂₃FN₄O₃S 
• 1443744-72-6 (R)-7-amino-4-(3-fluoropyrrolidine-1-carbonyl)-2-(4-methoxyphenyl)thieno[3,4-d]pyridazin-1(2H)-one 
• 1443744-71-5 5-amino-N-(2-fluoroethyl)-3-(4-methoxyphenyl)-4-oxo-3,4-dihydrothienor3,4-dlpyridazine-1-carboxamide 
• 1443744-70-4 C₂₈H₂₉FN₆O₅S 
• 1443745-34-3 C₂₃H₂₁FN₆O₃S 
• 1443745-72-9 C₁₈H₂₀N₄O₃S 

Relevant articles and documents

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block

Discovery of novel 7-azaindole derivatives bearing dihydropyridazine moiety as c-Met kinase inhibitors

A series of 7-azaindole derivatives bearing the dihydropyridazine scaffold were synthesized and evaluated for their c-Met kinase inhibitory, and antiproliferative activity against 4 cancer cell lines (HT29, A549, H460, U87MG) were evaluated in?vitro. Most compounds showed moderate to excellent potency. Compared to foretinib, the most promising analog 34 (c-Met IC50: 1.06?nM, a multitarget tyrosine kinase inhibitor) showed a 6.4-, 7.8-, and 3.2-fold increase in activity against HT29, A549, and H460?cell lines, respectively. Structure activity relationship studies indicated that mono-EWGs (such as R2?=?F) at 4-position of moiety D was a key factor in improving the antitumor activity.

Microwave assisted synthesis and biological activity of 4-(2-(aryl substituted) hydrazono)-1-(2-(p-tolyloxyacetyl)-3-methyl-1H-pyrazol- 5-one

A novel series of 4-(2-(aryl substituted) hydrazono)-1-(2-(p-tolyloxy) acetyl)-3-methyl- 1H-pyrazol-5-ones 3(a-j) was prepared by the reaction of ethyl-2-arylhydrazono -3- oxobutyrate and p-tolyloxyacethydrazide under microwave irradiation. The structures of the synthesized compounds were established by their spectral and analytical data. All the new compounds were screened for their antibacterial and antifungal activity.