123566-33-6

Basic information

• Product Name: (1-BENZYL-1H-IMIDAZOL-2-YL)-ACETIC ACID
• Synonyms: (1-BENZYL-1H-IMIDAZOL-2-YL)-ACETIC ACID
• CAS NO: 123566-33-6
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Mol File: 123566-33-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 427.2°C at 760 mmHg
• Flash Point: 212.1°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 4.67E-08mmHg at 25°C
• Refractive Index: 1.603
• PKA: 3.48±0.10(Predicted)
• CAS DataBase Reference: (1-BENZYL-1H-IMIDAZOL-2-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1-BENZYL-1H-IMIDAZOL-2-YL)-ACETIC ACID(123566-33-6)
• EPA Substance Registry System: (1-BENZYL-1H-IMIDAZOL-2-YL)-ACETIC ACID(123566-33-6)

Safety Data

• Hazardous Substances Data: 123566-33-6(Hazardous Substances Data)

Usage

Uses

(1-Benzyl-1H-imidazol-2-yl)-acetic Acid can be used as inhibitors of c-fms kinase.

InChI:InChI=1/C12H12N2O2/c15-12(16)8-11-13-6-7-14(11)9-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,15,16)

Upstream product

• 13750-62-4 N-benzyl-2-methylimidazole 
• 123566-36-9 benzyl 1-benzylimidazole-2-acetate 

Downstream Products

• 211103-73-0 tert-butyl (S)-N-[2-(4-{[2-(1-benzylimidazol-2-yl)acetyl]-N-(propyl)amino}phenyl)-ethyl]-N-(2-hydroxy-3-phenoxypropyl)carbamate 
• 131654-58-5 1-hydroxy-2-(1-benzylimidazol-2-yl)ethylidene-1,1-bisphosphonic acid 

Relevant articles and documents

Some Benzyl-Substituted Imidazoles, Triazoles, Tetrazoles, Pyridinethiones, and Structural Relatives as Multisubstrate Inhibitors of Dopamine β-Hydroxylase. 4. Structure-Activity Relationships at the Copper Binding Site

Structure-activity relationships (SAR) were determined for novel multisubstrate inhibitors of dopamine β-hydroxylase (DBH; EC 1.14.17.1) by examining the effects upon in vitro inhibitory potencies resulting from structural changes at the copper-binding region of inhibitor.Attempts were made to determine replacement groups for the thione sulfur atom of the prototypical inhibitor 1-(4-hydroxybenzyl)imidazole-2-thione described previously.The synthesis and evaluation of oxygen and nitrogen analogues of the soft thione group demonstrated the sulfur atom to be necessary for optimal activity.An additional series of imidazole-2-thione relatives was prepared in an effort to probe the relationship between the pKa of the ligand group and inhibitor potency.In vitro inhibitory potency was shown not to correlate with ligand pKa over a range of approximately 10 pKa units, and a rationale for this is advanced.Additional ligand modifications were prepared in order to explore bulk tolerance at the enzyme oxygen binding site and to determine the effects of substituting a six-membered ligand group for the five-membered imidazole-2-thione ligand.