13750-62-4Relevant articles and documents
Structural characterization of a new cobalt(II) complex of 1-benzyl-5-methyl-1H-imidazole
Bouchouit,Bouraiou,Bouacida,Belfaitah,Merazig
, p. 835 - 839 (2016)
The preparation of a cobalt(II) chloride complex with a N-donor ligand 1-benzyl-5-methyl-1H-imidazole of formula [CoCl2(1-benzyl-5-methyl-1H-imidazole)2] is described. The isolated complex was characterized by UV, IR spectroscopy and crystallographic studies. Single crystal X-ray diffraction analysis of the complex reveals its monomeric tetra-coordinated nature. The coordination polyhedron around the cobalt center can be described as a quasi-regular tetrahedron. The Co–N distances for this compound are 2.0111(17) ? and 2.0118(17) ?, while the Co–Cl distances are 2.2582(7) ? and 2.2549(7) ?. The crystal packing can be described as layers parallel to (101) plane alternating along the b axis, and it is stabilized by π–π stacking between the imidazole and phenyl rings. The shortest centroid–centroid distance is 3.6002(14) ?.
Atom Transfer Radical Polymerization-Inspired Room Temperature (sp3)C-N Coupling
Coote, Michelle L.,Fung, Alfred. K. K.,Sherburn, Michael S.,Yu, Li-Juan
, p. 9723 - 9732 (2021/07/20)
A simple nonphotochemical procedure is reported for Cu(I)-catalyzed C-N coupling of aliphatic halides with amines and amides. The process is loosely based on the Goldberg reaction but takes place readily at room temperature. It uses Cu(I)Br, a commonly used and inexpensive atom transfer radical polymerization precatalyst, along with the cheap ligand N,N,N′,N″,N″-pentamethyldiethylenetriamine, to activate the R-X bond of the substrate via inner-sphere electron transfer. The procedure brings about productive C-N bond formation between a range of alkyl halide substrates with heterocyclic aromatic amines and amides. The mechanism of the coupling step, which was elucidated through application of computational methods, proceeds via a unique Cu(I) → Cu(II) → Cu(III) → Cu(I) catalytic cycle, involving (a) inner-sphere electron transfer from Cu(I) to the alkyl halide to generate the alkyl radical; (b) successive coordination of the N-nucleophile and the radical to Cu(II); and finally reductive elimination. In the absence of a nucleophile, debrominative homocoupling of the alkyl halide occurs. Control experiments rule out SN-type mechanisms for C-N bond formation.
Synthesis and investigation of inhibitory activities of imidazole derivatives against the metallo-β-lactamase IMP-1
Khalili Arjomandi, Omid,Kavoosi, Mahboubeh,Adibi, Hadi
, (2019/09/19)
Mutations in bacteria can result in antibiotic resistance due to the overuse or abuse of β-lactam antibiotics. One strategy which bacteria can become resistance toward antibiotics is secreting of metallo β-lactamase enzymes that can open the lactam ring of the β-lactam antibiotic and inactivate them. This issue is a threat for human health and one strategy to overcome this situation is co-administration of β-lactam antibiotics with an inhibitor. So far, no clinically available inhibitors of metallo β-lactamases (MBLs) reported and the clinically inhibitors of serine β-lactamase are useless for MBLs. Accordingly, finding a potent inhibitor of the MBLs being very important. In this study, imidazole derivatives primarily were synthesized and their inhibitory activity were measured. Later in silico binding model was used to predict the configuration and conformation of the ligands into the active site of enzyme. Two molecules demonstrated with IC50 of 39 μM and 46 μM against MBL (IMP-1).
PALLADIUM PINCER COMPLEX OF NORMAL AND ABNORMAL CARBENE, PREPARATION METHOD FOR THE SAME AND USES THEREOF
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Paragraph 0034; 0035, (2016/10/08)
Palladium pincer complexes of both normal and abnormal carbene and preparation methods thereof are disclosed. Furthermore, uses of palladium pincer complexes of normal and abnormal carbene and pharmaceutical applications thereof are disclosed. Palladium pincer complex of normal and abnormal carbene are useful catalysts for C-C coupling reaction and therapeutic drugs for inhibiting tumor cell proliferation.
