1235840-44-4Relevant academic research and scientific papers
1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka
Arbuckle, Wullie,Baugh, Mark,Belshaw, Simone,Bennett, D. Jonathan,Bruin, John,Cai, Jiaqiang,Cameron, Kenneth S.,Claxton, Chris,Dempster, Maureen,Everett, Kathryn,Fradera, Xavier,Hamilton, William,Jones, Philip S.,Kinghorn, Emma,Long, Clive,Martin, Iain,Robinson, John,Westwood, Paul
scheme or table, p. 932 - 935 (2011/03/21)
Based on the theoretical understanding of the in vivo lysosomotropism, by adjusting the pka of basic nitrogen containing cathepsin S inhibitors, a set of compounds with pka 6-8 were identified to have excellent cell based Lip10 activ
