1235840-52-4Relevant academic research and scientific papers
1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka
Arbuckle, Wullie,Baugh, Mark,Belshaw, Simone,Bennett, D. Jonathan,Bruin, John,Cai, Jiaqiang,Cameron, Kenneth S.,Claxton, Chris,Dempster, Maureen,Everett, Kathryn,Fradera, Xavier,Hamilton, William,Jones, Philip S.,Kinghorn, Emma,Long, Clive,Martin, Iain,Robinson, John,Westwood, Paul
scheme or table, p. 932 - 935 (2011/03/21)
Based on the theoretical understanding of the in vivo lysosomotropism, by adjusting the pka of basic nitrogen containing cathepsin S inhibitors, a set of compounds with pka 6-8 were identified to have excellent cell based Lip10 activ
6-PHENYL-LH-IMIDAZO [4, 5-C] PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS
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Page/Page column 49, (2010/08/08)
The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I) to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament
6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES
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Page/Page column 26, (2010/08/07)
The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament f
