1235868-29-7

Upstream product

• 868765-12-2 2-phenylethynyl-quinoline-3-carbaldehyde 
• 67-56-1 methanol 
• 536-74-3 phenylacetylene 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 

Downstream Products

• 1256286-30-2 4-(4-ethylphenyl)-1-methoxy-3-phenyl-1H-pyrano[4,3-b]quinoline 
• 1256286-29-9 1-methoxy-3,4-diphenyl-1H-pyrano[4,3-b]quinoline 
• 1320362-74-0 C₃₁H₂₇NO₂ 
• 1320362-71-7 C₂₉H₂₃NO₂ 
• 1320362-11-5 C₂₆H₂₁NO₃ 
• 1320362-14-8 C₂₆H₂₁NO₂S 
• 1320362-75-1 1-methoxy-4-((4-methoxyphenyl)ethynyl)-3-phenyl-1H-pyrano[4,3-b]quinoline 
• 1320362-72-8 1-methoxy-3-phenyl-4-(p-tolylethynyl)-1H-pyrano[4,3-b]quinoline 
• 1401829-06-8 3-benzoyl-1-(hydroxymethyl)-2-(p-tolyl)pyrrolo[1,2-a]quinoline-4-carbaldehyde 
• 1401829-04-6 C₃₃H₂₃NO₃ 
• 1401829-02-4 3-benzoyl-1-(4-methoxyphenyl)-2-phenylpyrrolo[1,2-a]quinoline-4-carbaldehyde 
• 1401828-70-3 3-benzoyl-1,2-di-p-tolylpyrrolo[1,2-a]quinoline-4-carbaldehyde 
• 1401828-67-8 3-benzoyl-1,2-diphenylpyrrolo[1,2-a]quinoline-4-carbaldehyde 
• 1401828-69-0 3-benzoyl-1,2-bis(4-methoxyphenyl)pyrrolo[1,2-a]quinoline-4-carbaldehyde 

Relevant academic research and scientific papers

Site-selective electrophilic cyclization and subsequent ring-opening: A synthetic route to pyrrolo[1,2-a]quinolines and indolizines

An efficient strategy for the synthesis of pyrrolo[1,2-a]quinolines and indolizines from pyranoquinolines via site-selective electrophilic cyclization and subsequent opening of pyran ring using silver/iodine under mild reaction conditions is described. Th

Pyrano[4,3-b]quinolines library generation via iodocyclization and palladium-catalyzed coupling reactions

Synthesis of a 80-member library of novel pyrano[4,3-b]quinolines in solution-phase is reported. The key intermediate, 4-iodopyrano[4,3-b]quinolines were synthesized by the electrophilic iodocyclization of corresponding ortho-alkynyl aldehydes in good to

Base-free NIS promoted electrophilic cyclization of alkynes: An efficient synthesis of iodo substituted pyrano[4,3-b]quinolines

A simple and mild procedure for the synthesis of iodo substituted 1H-pyrano[4,3-b]quinolines has been achieved using NIS reagent in the absence of base from 2-alkynylquinoline-3-carboxaldehydes via intramolecular electrophilic cyclization onto alkynes in good to excellent yields in a short duration of time. The reactions proceeded smoothly in a normal solvent in aerobic atmosphere at room temperature. The presence of substituent at either quinoline or alkyne moieties did not show effect on reaction rate of cyclization. The palladium-catalyzed transformations of iodo group to C-C bond are also discussed. Copyright

Iodine-catalyzed and solvent-controlled selective electrophilic cyclization and oxidative esterification of ortho-alkynyl aldehydes

4-Iodo-pyrano[4,3-b]quinolines and ortho-alkynyl esters were synthesized selectively from ortho-alkynyl aldehydes by an iodine-catalyzed and solvent controlled reaction.

Iodine-mediated solvent-controlled selective electrophilic cyclization and oxidative esterification of o-alkynyl aldehydes: An easy access to pyranoquinolines, pyranoquinolinones, and isocumarins

Chemoselective behavior of iodine in different solvents in the electrophilic iodocyclization of o-alkynyl aldehydes is described. o-Alkynyl aldehydes 3a-t on reaction with I2 in CH2Cl2 with appropriate nucleophiles provides pyrano[4,3-b]quinolines 4a-f, via formation of cyclic iodonium intermediate Q; however, using alcohols as a solvent as well as nucleophile, o-alkynyl esters 5a-y were obtained selectively in good to excellent yields via formation of hypoiodide intermediate R. Subsequently, o-alkynyl esters were converted in to pyranoquinolinones 6a-i and isocoumarin 6j by electrophilic iodocyclization. This developed oxidative esterification provides a novel access for the chemoselective synthesis of esters 5q-u from aldehydes 3n-p without oxidizing primary alcohol present in the substrate.