1235871-72-3

Upstream product

• 213698-40-9 1-(N-tert-butoxycarbonylamino)-6,7-dimethoxynaphthalene 
• 92-44-4 2,3-naphthalenediol 
• 77542-54-2 5-nitro-2,3-dihydroxynaphthalene 
• 56517-24-9 6,7-bis(methylsulfonyloxy)-1-nitronaphthalene 
• 22426-45-5 2,3-bis(methylsulfonyloxy)naphthalene 
• 1235871-71-2 1-(N-tert-butoxycarbonylamino)-4-biphenyl-6,7-dimethoxynaphthalene 
• 7311-22-0 2,3-dimethoxy-5-nitronaphthalene 
• 1235871-76-7 4-iodo-6,7-dimethoxy-1-naphthylamine 
• 5122-94-1 4-biphenylboronic acid 
• 52401-42-0 1-amino-6,7-dimethoxynaphthalene 

Downstream Products

• 1235871-73-4 N-(4-(biphenyl-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromobenzo[1,3]dioxole-4-carboxamide 
• 1353554-92-3 C₂₆H₂₅NO₂ 
• 1235871-25-6 C₃₄H₃₀NO₄⁽¹⁺⁾*Cl^(1-) 
• 1235871-14-3 C₃₃H₂₆NO₄⁽¹⁺⁾*Cl^(1-) 
• 1235871-74-5 N-(4-(biphenyl-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide 
• 1235872-14-6 C₃₄H₃₀BrNO₅ 
• 1235871-75-6 7-(biphenyl-4-yl)-9,10-dimethoxy-12-methylbenzo[1,3]dioxolo[4,5]phenanthridin-13(12H)-one 
• 1235872-15-7 C₃₄H₂₉NO₅ 

Relevant academic research and scientific papers

Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives

Antibiotic resistance has prompted efforts to discover antibiotics with novel mechanisms of action. FtsZ is an essential protein for bacterial cell division, and has been viewed as an attractive target for the development of new antibiotics. Sanguinarine is a benzophenanthridine alkaloid that prevents cytokinesis in bacteria by inhibiting FtsZ self-assembly. In this study, a series of 5-methylbenzo[c]phenanthridinium derivatives were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and Enterococcus faecalis. The data indicate that the presence of a 1- or 12-phenyl substituent on 2,3,8,9-tetramethoxy-5-methylbenzo[c]phenanthridinium chloride significantly enhances antibacterial activity relative to the parent compound or sanguinarine.

BENZO [C] PHENANTHRIDINES AS ANTIMICROBIAL AGENTS

The present invention provides compounds of formula I: formula (I) wherein X1- X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecu