1235872-20-4

Basic information

• Product Name: C₁₅H₁₄F₃N₃O₈
• Synonyms: C₁₅H₁₄F₃N₃O₈
• CAS NO: 1235872-20-4
• Molecular Weight: 421.287
• Mol File: 1235872-20-4.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₄F₃N₃O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₄F₃N₃O₈(1235872-20-4)
• EPA Substance Registry System: C₁₅H₁₄F₃N₃O₈(1235872-20-4)

Safety Data

• Hazardous Substances Data: 1235872-20-4(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 528-75-6 2,4-dinitrobenzaldehyde 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Relevant articles and documents

Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations

One-pot four-component reactions of aromatic aldehyde, Meldrum's acid, ethyl-4,4,4-trifluoro-1,3-dioxobutanoate, and ammonium acetate afford ethyl 2-hydroxy-6-oxo-4-aryl-2-(trifluoromethyl)piperidine-3-carboxylate in good yields. The one-pot four-component process consists of an initial Michael addition, and a subsequent intramolecular cyclization. The effect of solvents on the reaction efficiency and yield is briefly investigated. The structure of product is further confirmed by XRD analysis. Meanwhile, the further transformation of hemi-aminal moiety to the corresponding dehydrated product is also achieved under the mild reaction conditions. The possible mechanism for the formation of product is presented.