1235974-40-9Relevant academic research and scientific papers
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors
Liang, Yong-Hong,He, Qiu-Qin,Zeng, Zhao-Sen,Liu, Zhi-Qian,Feng, Xiao-Qing,Chen, Fen-Er,Balzarini, Jan,Pannecouque, Christophe,Clercq, Erik De
, p. 4601 - 4605 (2010)
Nine newly 6-cynao-2-naphthyl substituted diarylpyrimidines (DAPY) were synthesized as non-nucleoside reverse transcriptase inhibitors on the basis of our previous work. The antiviral and cytotoxicity evaluation indicated that these compounds displayed strong activity against wild-type HIV-1 at nanomolar concentrations with selectivity index SI greater than 23 779. The most active compounds 3c and 3e exhibited activity against the double mutant (103N+181C) strains at an EC50 of 0.16 and 0.15 μM, and were more activity than that of efavirenz.
