1235989-03-3

Basic information

• Product Name: (R)-3-(4-chlorophenyl)-3-methylcyclohexan-1-one
• Synonyms: (R)-3-(4-chlorophenyl)-3-methylcyclohexan-1-one
• CAS NO: 1235989-03-3
• Molecular Weight: 222.715
• Mol File: 1235989-03-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-3-(4-chlorophenyl)-3-methylcyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-chlorophenyl)-3-methylcyclohexan-1-one(1235989-03-3)
• EPA Substance Registry System: (R)-3-(4-chlorophenyl)-3-methylcyclohexan-1-one(1235989-03-3)

Safety Data

• Hazardous Substances Data: 1235989-03-3(Hazardous Substances Data)

Upstream product

• 1193-18-6 3-methylcyclohexen-2-one 
• 1679-18-1 4-Chlorophenylboronic acid 
• 7519-91-7 tris(4-chlorophenyl)boroxine 

Relevant articles and documents

Recoverable polystyrene-supported palladium catalyst for construction of all-carbon quaternary stereocenters via asymmetric 1,4-addition of arylboronic acids to cyclic enones

The development of recoverable catalysts based on the combination of synthetically demanding ligands with transition metals attracts a lot of attention, especially from the environmental point of view. In this paper, we describe the preparation of a recoverable polystyrene supported chiral palladium catalyst based on PyOx ligand suitable for asymmetric 1,4-addition of arylboronic acids to cyclic 3-substituted five- and six-membered enones. In the reaction, all?carbon quaternary stereocenters are formed with a high level of enantioselectivity (up to 91% ee) and conversion (up to 99%). The catalyst was used in 6 cycles with no loss of enantioselectivity and only a small decrease in conversion. A solution of the problems associated with the transition from homogeneous to heterogeneous catalytic systems is discussed.

Synthesis of diverse β-quaternary ketones via palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enones

Abstract The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enone conjugate acceptors is described. These reactions employ air-stable and readily-available reagents in an operationally si

Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to five-, six-, and seven-membered β-substituted cyclic enones: enantioselective construction of all-carbon quaternary stereocenters

The first enantioselective Pd-catalyzed construction of all-carbon quaternary stereocenters via 1,4-addition of arylboronic acids to β-substituted cyclic enones is reported. Reaction of a wide range of arylboronic acids and cyclic enones using a catalyst