1235989-53-3

Upstream product

• 6118-51-0 exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 
• 107-15-3 ethylenediamine 

Downstream Products

• 1235989-50-0 6,6'-(ethane-1,2-diyl)bis[rel-(3aR,4S,4aR,7aS,8S,8aR)-4,8-epoxy-1-phenyl-3-(2,3-dichlorophenyl)-4,4a,6,7a,8,8a-hexahydropyrrolo[3,4-f]indazole-5,7(1H,3aH)-dione] 
• 1235989-52-2 6,6'-(ethane-1,2-diyl)bis[rel-(3aR,4S,4aR,7aS,8S,8aR)-4,8-epoxy-1-phenyl-3-(2-phenyl-2H-1,2,3-triazol-4-yl)-4,4a,6,7a,8,8a-hexahydropyrrolo[3,4-f]indazole-5,7(1H,3aH)-dione] 
• 1235989-45-3 6,6'-(ethane-1,2-diyl)bis[exo,exo-4,8-epoxy-3a,4,4a,7a,8,8ahexahydro-3-(4-(methylsulfinyl)phenyl)-pyrrolo[3,4-f]-1,2-benzisoxazole-5,7(1H,3aH)-dione] 
• 1235989-49-7 6,6'-(ethane-1,2-diyl)bis[rel-(3aR,4S,4aR,7aS,8S,8aR)-4,8-epoxy-1-phenyl-3-(2-chlorophenyl)-4,4a,6,7a,8,8a-hexahydropyrrolo[3,4-f]indazole-5,7(1H,3aH)-dione] 
• 1235989-43-1 6,6'-(ethane-1,2-diyl)bis[exo,exo-4,8-epoxy-3a,4,4a,7a,8,8ahexahydro-3-(4-fluorophenyl)-pyrrolo[3,4-f]-1,2-benzisoxazole-5,7(1H,3aH)-dione] 
• 1235989-48-6 6,6'-(ethane-1,2-diyl)bis[rel-(3aR,4S,4aR,7aS,8S,8aR)-4,8-epoxy-1,3-diphenyl-4,4a,6,7a,8,8a-hexahydropyrrolo[3,4-f]indazole-5,7(1H,3aH)-dione] 
• 1235989-44-2 6,6'-(ethane-1,2-diyl)bis[exo,exo-4,8-epoxy-3a,4,4a,7a,8,8ahexahydro-3-(4-chlorophenyl)-pyrrolo[3,4-f]-1,2-benzisoxazole-5,7(1H,3aH)-dione] 
• 1235989-46-4 6,6'-(ethane-1,2-diyl)bis[exo,exo-4,8-epoxy-3a,4,4a,7a,8,8ahexahydro-3-(3-hydroxy-4-methoxyphenyl)-pyrrolo[3,4-f]-1,2-benzisoxazole-5,7(1H,3aH)-dione] 
• 1235989-51-1 6,6'-(ethane-1,2-diyl)bis[rel-(3aR,4S,4aR,7aS,8S,8aR)-4,8-epoxy-1-phenyl-3-(quinoxalin-2-yl)-4,4a,6,7a,8,8a-hexahydropyrrolo[3,4-f]indazole-5,7(1H,3aH)-dione] 

Relevant academic research and scientific papers

Synthesis of norcantharidin-dimer derivatives

We use one molecule of ethylene diamine as a connecting arm to combine two molecules of 5,6-dehydronorcantharidin. Then, ten novel norcantharidin derivatives were synthesized in a single step by the [3 + 2] 1,3-dipolar cycloaddition reaction with oxime or hydrazone in the presence of chloramine-T, which is simpler than the conventional method.