1235994-45-2

Upstream product

• 139112-63-3 2,2-difluoropent-4-enenitrile 
• 89708-79-2 (R)-(+)-allyl p-tolyl sulphoxide 
• 623-47-2 propynoic acid ethyl ester 
• 1235994-36-1 (+)-(1E,3Z)-5,5-difluoro-1-[(R)-p-tolylsulfinyl]octa-1,3,7-trien-4-amine 

Downstream Products

• 1235994-52-1 (+)-ethyl N-benzyloxycarbonyl-6-(1,1-difluorobut-3-enyl)-4-[(R)-p-tolylsulfinylmethyl]-1,4-dihydropyridin-3-carboxylate 

Relevant academic research and scientific papers

Tandem asymmetric Michael reaction-intramolecular Michael addition. An easy entry to chiral fluorinated 1,4-dihydropyridines

(Equation Presented). A novel one-pot tandem asymmetric Hantzsch-type process has been employed to generate fluorinated 1,4-dihydropyridines (1,4-DHPs) as single diastereoisomers. It involves the condensation of (R)-(+)-allyl p-tolyl sulfoxide, fluorinated nitriles, and alkyl propiolates, giving access to a new family of enantiomerically pure fluorine-containing 1,4-DHPs.