1236077-61-4

Basic information

• Product Name: (S)-5-((benzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
• Synonyms: (S)-5-((benzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one
• CAS NO: 1236077-61-4
• Molecular Weight: 385.438
• Mol File: 1236077-61-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-5-((benzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-((benzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one(1236077-61-4)
• EPA Substance Registry System: (S)-5-((benzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one(1236077-61-4)

Safety Data

• Hazardous Substances Data: 1236077-61-4(Hazardous Substances Data)

Upstream product

• 1236077-59-0 (5S)-(N)-[[(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]bromide 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 565176-83-2 N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline 
• 168828-82-8 (R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol 
• 2689-39-6 3-fluoro-4-(4-morpholinyl)nitrobenzene 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 168828-81-7 benzyl 3-fluoro-4-(4-morpholinyl)phenylcarbamate 
• 369-34-6 3,4-difluoronitrobenzene 
• 168828-83-9 (R)-[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl 4-methylbenzenesulfonate 

Downstream Products

• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 165800-03-3 linezolid 

Relevant articles and documents

Asymmetric synthesis of linezolid thiazolidine-2-thione derivatives via CS2 mediated decarboxylation cyclization

A mild and cost-effective decarboxylation cyclization method was developed for the synthesis of chiral 5-substituted thiazolidine-2-thione derivatives from β-amino oxazolidinones. This reaction was mediated by CS2 and allowed a highly stereoselective synthesis of linezolid thiazolidine-2-thione derivatives. The chirality of the linezolid base was completely retained in the final product.

A PROCESS FOR THE PREPARATION OF (5S)-(N)-[[3-[3-FLUORO-4-(4-MORPHOLINYL) PHENYL]-2-OXO-5-OXAZOLIDINYL] METHYL] ACETAMIDE

The present invention is directed to a novel, industrially viable, cost effective process for manufacturing (5S)-N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide going through a novel intermediate of Formula XXI and XXII.