1236144-37-8

Basic information

• Product Name: 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
• Synonyms: 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
• CAS NO: 1236144-37-8
• Molecular Weight: 471.395
• Mol File: 1236144-37-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid(1236144-37-8)
• EPA Substance Registry System: 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid(1236144-37-8)

Safety Data

• Hazardous Substances Data: 1236144-37-8(Hazardous Substances Data)

Upstream product

• 1236144-59-4 tert-butyl 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 
• 105-07-7 4-cyanobenzaldehyde 
• 1193-96-0 (E)-pyridin-2-aldoxime 
• 1236144-62-9 5-(4-iodo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole 
• 1236144-56-1 ethyl 3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazole-5-carboxylate 
• 1236144-53-8 tert-butyl 1-(4-cyanobenzyl)azetidine-3-carboxylate 
• 1236144-58-3 3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazole-5-carboxylic acid 
• 1236144-54-9 tert-butyl 1-(4-(N′-hydroxycarbamimidoyl)benzyl)azetidine-3-carboxylate 
• 1236144-55-0 1-(4-cyanobenzyl)azetidine-3-carboxylic acid 
• 69716-28-5 2-pyridylhydroxyiminomethyl chloride 
• 439126-55-3 3-(pyridin-2-yl)isoxazole-5-carboxylic acid ethyl ester 
• 1236144-61-8 5-(4-bromo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole 
• 1236144-63-0 5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole 
• 1236144-64-1 3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole 

Relevant articles and documents

Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1)

The synthesis and structure-activity relationship (SAR) of a series of pyridyl-isoxazole based agonists of S1P1 are discussed. Compound 5b provided potent in vitro activity with selectivity, had an acceptable pharmacokinetic profile, and demonstrated efficacy in a dose dependent manner when administered orally in a rodent model of arthritis.