1236144-62-9

Basic information

• Product Name: 5-(4-iodo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole
• Synonyms: 5-(4-iodo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole
• CAS NO: 1236144-62-9
• Molecular Weight: 430.204
• Mol File: 1236144-62-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-iodo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-iodo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole(1236144-62-9)
• EPA Substance Registry System: 5-(4-iodo-3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole(1236144-62-9)

Safety Data

• Hazardous Substances Data: 1236144-62-9(Hazardous Substances Data)

Upstream product

• 439126-55-3 3-(pyridin-2-yl)isoxazole-5-carboxylic acid ethyl ester 
• 69716-28-5 (Z)-picolinaldehyde (α)-chloro-oxime 
• 1236144-60-7 5-(3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole 

Downstream Products

• 1236144-63-0 5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole 
• 1236144-64-1 3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole 
• 1236144-37-8 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid 
• 1236144-59-4 tert-butyl 1-(4-(5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylate 

Relevant articles and documents

SUBSTITUTED OXADIAZOLE DERIVATIVES AS S1P AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES

[00180] Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein Q is or R1 is cycloalkyl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, -OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as vascular disease and autoimmune diseases.