1236147-97-9Relevant academic research and scientific papers
Synthesis of fluoromethyl-containing analogs of antitumor alkaloid luotonin A
Golubev,Bogomolov,Shidlovskii,Dezhenkova,Peregudov,Shtil,Chkanikov
, p. 209 - 218 (2011/01/07)
A convenient method for the synthesis of hitherto unknown 3-bromomethyl-2-chloro-4-fluoromethylquinolines has been developed. Coupling of 3-bromomethyl-2-chloro-4-trifluoromethylquinoline with 4(3H)-quinazolinone with subsequent intramolecular Heck cyclization leads to 7-trifluoromethylluotonin, an analog of the antitumor alkaloid luotonin A. 7-Trifluoromethylluotonin retains the antitumor activity including apoptosis of cultured tumor cells and inhibiting DNA-topoisomerase I.
