1236156-65-2

Basic information

• Product Name: 2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester
• Synonyms: 2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester
• CAS NO: 1236156-65-2
• Molecular Weight: 556.621
• Mol File: 1236156-65-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester(1236156-65-2)
• EPA Substance Registry System: 2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-aminobenzoic acid-1-(((cyclohexyloxy)carbonyl)oxy)ethyl ester(1236156-65-2)

Safety Data

• Hazardous Substances Data: 1236156-65-2(Hazardous Substances Data)

Upstream product

• 1073117-29-9 (+/-)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-[[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]amino]-3-nitrobenzoate 

Downstream Products

• 145040-37-5 candesartan cilexetil 

Relevant articles and documents

Preparation method of candesartan cilexetil and intermediate of candesartan cilexetil

The invention relates to a preparation method of candesartan cilexetil and an intermediate of the candesartan cilexetil. The intermediate is hydrogenated to remove benzyloxycarbonyl and triphenylmethyl protecting groups in the presence of Pd/C, and nitro is reduced to amino, so that the 'one-pot multi-step' operation is realized, no acid is needed during deprotection, side-chain cyclohexyl carbonate degradation is avoided, the product purity is high, and the candesartan cilexetil is prepared by cyclization. According to the preparation method of candesartan cilexetil and the intermediate of the candesartan cilexetil disclosed by the invention, the problems in the prior art that side chains are degraded when common t-butyloxycarboryl protecting groups on amino are removed under strong acidconditions and triphenylmethyl protecting groups on tetrazole are transferred to amino are solved.