1073117-29-9Relevant academic research and scientific papers
Novel and practical synthesis of candesartan cilexetil
Mao, Yongjun,Xiong, Ruisheng,Liu, Zheng,Li, Haihong,Shen, Jingkang,Shen, Jingshan
, p. 1503 - 1508 (2010)
A novel and convergent synthetic route of candesartan cilexetil (API of Atacand), an effective angiotensin II receptor blocker, is described. Cleavage of the N-Boc and N-trityl protective group are implemented simultaneously and formation of the benzimidazole ring is conducted at the last step of this route, which gives candesartan cilexetil in 55% yield over six steps with 99.1% purity (HPLC).
