1236168-49-2Relevant academic research and scientific papers
Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions
Ramachary, Dhevalapally B.,Mondal, Rumpa,Venkaiah, Chintalapudi
supporting information; experimental part, p. 321 - 325 (2010/02/16)
An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels-Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.
Rapid Synthesis of Functionalized Indenes, Triazoles, and Glucocorticoid Receptor Modulators by Sequential Multicatalysis Cascade Reactions
Ramachary, Dhevalapally B.,Mondal, Rumpa,Venkaiah, Chintalapudi
supporting information; experimental part, p. 3205 - 3210 (2010/08/20)
A general process for the synthesis of substituted indenes and 1,2,3-triazoles was achieved, for the first time through a multicatalysis cascade reaction of 2-ethynylbenzaldehydes, CH acids, organic hydrides, and azides in the presence of a catalytic amount of L-proline/CuI/DIPEA. In this communication, we discovered the utilization of a single copper catalyst for two different reactions and shown synthetic application to the high-yielding synthesis of glucocorticoid receptor modulators.
