123618-00-8

Basic information

• Product Name: fedotozine
• Synonyms: fedotozine;[R,(+)]-1-Phenyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-N,N-dimethylpropan-1-amine;JO-1196
• CAS NO: 123618-00-8
• Molecular Formula: C22H13NO4
• Molecular Weight: 0
• Mol File: 123618-00-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 453°Cat760mmHg
• Flash Point: 120.9°C
• Appearance: /
• Density: 1.061g/cm³
• Vapor Pressure: 2.14E-08mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: fedotozine(CAS DataBase Reference)
• NIST Chemistry Reference: fedotozine(123618-00-8)
• EPA Substance Registry System: fedotozine(123618-00-8)

Safety Data

• Hazardous Substances Data: 123618-00-8(Hazardous Substances Data)

Usage

Uses

Fedotozine is a kappa (κ) opioid receptor agonist used in irritable bowel syndromes (IBS). A potential visceral analgesic.

InChI:InChI=1/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1

Upstream product

• 123-91-1 1,4-dioxane 
• 39068-94-5 2-phenyl-2-dimethylamino-1-butanol 

Related news

The κ agonist fedotozine (cas 123618-00-8) modulates colonic distention-induced inhibition of gastric motility and emptying in dogs08/11/2019

Background/Aims: Gastric motor disturbances, associated with a delay in gastric emptying, occur in patients with the irritable bowel syndrome. The influence of fedotozine and κ agonists on the cologastric reflex produced by nonpainful colonic distention was evaluated in conscious dogs. Methods:...detailed

fedotozine (cas 123618-00-8) reverses ileus induced by surgery or peritonitis: Action at peripheral Κ-Opioid receptors08/10/2019

Background: Fedotozine is a peripheral opioid agonist. Its effects were assessed in experimental ileus in rats. Methods: Ileus was induced by abdominal surgery (laparotomy and cecum palpation) or peritonitis (acetic acid, intraperitoneally). Digestive motility was recorded by electromyography an...detailed

Effect of fedotozine (cas 123618-00-8) on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat08/09/2019

The effect of fedotozine was evaluated in a model of colonic hypersensibility to balloon distension in anesthetized rats. Acetic acid (0.6%, intracolonically) significantly enhanced the hypotension reflex response to colonic distension (Pdetailed

The κ agonist fedotozine (cas 123618-00-8) relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome08/08/2019

Background & Aims: Visceral hypersensitivity plays a major role in the pathophysiology of inflammatory bowel syndrome (IBS). Opioid κ receptors on afferent nerves may modulate it and may be the target of new IBS treatments. The aim of this study was to evaluate the effects of fedotozine, a pote...detailed

fedotozine (cas 123618-00-8) blocks hypersensitive visceral pain in conscious rats: action at peripheral κ-opioid receptors08/07/2019

The effect of fedotozine on visceral hypersensitivity was evaluated in conscious rats. One hour after colonic irritation (0.6% acetic acid intracolonically), a 30 mmHg colonic distension was applied for 10 min. Irritation increased the number of abdominal contractions induced by colonic distensi...detailed

Relevant articles and documents

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-N-propylamine, process for preparing it and its therapeutical use

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylamine of formula STR1 is a medicament of use in gastroenterology.