fedotozine (cas 123618-00-8) reverses ileus induced by surgery or peritonitis: Action at peripheral Κ-Opioid receptors

Add time:08/10/2019    Source:sciencedirect.com

Background: fedotozine (cas 123618-00-8) is a peripheral opioid agonist. Its effects were assessed in experimental ileus in rats. Methods: Ileus was induced by abdominal surgery (laparotomy and cecum palpation) or peritonitis (acetic acid, intraperitoneally). Digestive motility was recorded by electromyography and gastrointestinal transit estimated using a 51Cr-labeled test meal. Results: Surgery or peritonitis inhibited motility and migrating myoelectrical complexes for 2–3 hours. In both models, fedotozine (3 mg/kg, intravenously; 10 mg/kg, subcutaneously) restored a normal motility pattern. This action was reproduced by the Κ-agonist, U-50, and 488H and was blocked by subcutaneous naloxone, naloxone-methiodide, or nor-binaltorphimine, a selective Κ-antagonist. Peritonitis induced a 57% inhibition of gastric emptying and intestinal transit that was reversed by fedotozine (1–10 mg/kg, subcutaneously) or Κ-agonists (U-50, 488H, bremazocine) but not δ-agonists (DPDPE, [d-Ala2]-deltorphin-II), whereas μ-agonists (morphine, fentanyl) potentiated ileus. Fedotozine restoration of transit was blocked by subcutaneous naloxone, naloxone-methiodide, or nor-binaltorphimine but not by intracerebroventricular naloxone. Fedotozine was inactive up to 300 μg/rat when given intracerebroventrically or intrathecally. Conclusion: Fedotozine reverses experimental ileus via an action at peripheral Κ-opioid receptors.

We also recommend Trading Suppliers and Manufacturers of fedotozine (cas 123618-00-8). Pls Click Website Link as below: cas 123618-00-8 suppliers

Prev:Effect of fedotozine (cas 123618-00-8) on the cardiovascular pain reflex induced by distension of the irritated colon in the anesthetized rat
Next:The κ agonist fedotozine (cas 123618-00-8) modulates colonic distention-induced inhibition of gastric motility and emptying in dogs)