123619-53-4Relevant academic research and scientific papers
Mannich reactions of cephalosporin sulphoxides and sulphones with imonium salts. An improved synthesis of 2-methylene-cephalosporins
Gunda
, p. 2979 - 2986 (2007/10/02)
2-Methylenecephem-1-oxides (4) or -1,1-dioxides (6) can be very conveniently obtained through the use of dimethyl(methylene)imonium salts, which can be prepared in situ or in advance from bis(N,N-dimethylamino)methane (2) and a reactive acid derivative.
SYNTHESIS AND 1,3-DIPOLAR CYCLOADDITIONS OF 2-METHYLENECEPHALOSPORINS
Jaszberenyi J. Csaba,Pitlik Janos,Kollar Katalin,Petrikovics Ilona,Erdoedi-Koever Katalin,Batta Gyula
, p. 81 - 98 (2007/10/02)
Cephalosporin R- and S-sulphoxides were prepared.The S-sulphoxides gave Mannich-reaction resulting in the formation of 2-methylenecephalosporins.These electrom-deficient dienes underwent 1,3-dipolar cycloadditions with diazoalkanes in a chemo- and regiosp
